An insular view of the social decision-making network

Rogers-Carter, Morgan M.; Christianson, John P.

doi:10.1016/j.neubiorev.2019.06.005

Cited by 77 publications

(59 citation statements)

References 302 publications

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“…Social behavior requires multiple steps of information processing whereby multimodal sensory inputs are transformed into appropriate behavioral outputs via social decision-making. The IC is anatomically situated to integrate multisensory social cues to influence the activity of the evolutionally conserved "social decision-making network," which consists of the core nodes of the "social behavior network" and the mesolimbic reward system [32,35,36]. Our study directly observed the activity of AI neurons during social interaction at a single cell level and thus provides new insight into the cellular basis of the social function of the AI.…”

Section: Discussionmentioning

confidence: 85%

Encoding of social exploration by neural ensembles in the insular cortex

et al. 2020

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The insular cortex (IC) participates in diverse complex brain functions, including social function, yet their cellular bases remain to be fully understood. Using microendoscopic calcium imaging of the agranular insular cortex (AI) in mice interacting with freely moving and restrained social targets, we identified 2 subsets of AI neurons-a larger fraction of "Social-ON" cells and a smaller fraction of "Social-OFF" cells-that change their activity in opposite directions during social exploration. Social-ON cells included those that represented social investigation independent of location and consisted of multiple subsets, each of which was preferentially active during exploration under a particular behavioral state or with a particular target of physical contact. These results uncover a previously unknown function of AI neurons that may act to monitor the ongoing status of social exploration while an animal interacts with unfamiliar conspecifics.

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Section: Discussionmentioning

confidence: 85%

Encoding of social exploration by neural ensembles in the insular cortex

et al. 2020

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“…Oxytocin acting via the autonomic nervous system and acting on the cortex and brainstem has been repeatedly implicated in human social engagement, facially expressed emotions, and eye gaze ( Kemp et al, 2012 ; Quintana et al, 2013 ; Freeman and Young, 2016 ). Evidence from rodents indicates that the oxytocin receptor plays an important role in cortical functions necessary for social cognition ( Ophir, 2017 ), social reward ( Song et al, 2014 ), and social affective behavior ( Rogers-Carter et al, 2018 ; Rogers-Carter and Christianson, 2019 ). At least some of these effects also involve interactions between oxytocin and dopamine ( Quintana et al, 2019 ; Martins et al, 2020 ).…”

Section: The Autonomic Nervous System As a Target For Oxytocinmentioning

confidence: 99%

Is Oxytocin “Nature’s Medicine”?

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“…Moreover, recent work showed that rat hippocampal CA1 pyramidal neurons respond to social cues, triggering the somatosensory and auditory systems in a social stimulus-specific manner 31 and that touch may by a crucial component of the social reward associated with social place preference 32 . These studies raise the possibility that mice and rats integrate multimodal information during social interactions which can serve as a more complex basis for social recognition than the olfactory signature alone 33 . Accordingly, we challenged the common assumption that social recognition in mice and rats is solely based upon chemosensory cues in the present study.…”

Section: Introductionmentioning

confidence: 99%

Social recognition in rats and mice requires integration of olfactory, somatosensory and auditory cues

Netser

Magalnik

et al. 2020

Preprint

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In humans, discrimination between individuals, also termed social recognition, can rely on a single sensory modality, such as vision. By analogy, social recognition in rodents is thought to be based upon olfaction. Here, we hypothesized that social recognition in rodents relies upon integration of olfactory, auditory and somatosensory cues, hence requiring active behavior of social stimuli. Using distinct social recognition tests, we demonstrated that adult male rats and mice do not recognize familiar stimuli or learn the identity of novel stimuli that are inactive due to anesthesia. We further revealed that impairing the olfactory, somatosensory or auditory systems prevents recognition of familiar stimuli. Finally, we found that familiar and novel stimuli generate distinct movement patterns during social discrimination and that subjects react differentially to the movement of these stimuli. Thus, unlike what occurs in humans, social recognition in rats and mice relies on integration of information from several sensory modalities.

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An insular view of the social decision-making network

Cited by 77 publications

References 302 publications

Encoding of social exploration by neural ensembles in the insular cortex

Encoding of social exploration by neural ensembles in the insular cortex

Is Oxytocin “Nature’s Medicine”?

Social recognition in rats and mice requires integration of olfactory, somatosensory and auditory cues

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