The purpose of the research is the creation of an effective didactic system through the integrated approach to the content of natural education with a special emphasis on professional orientation. Methods of the analysis, synthesis of knowledge, educational experiment, and mathematical statistics were used for the fulfillment of the purpose. The effective didactic system of interdisciplinary knowledge of natural-science course, namely the water security course, was created. The educational experiment proved the effectiveness of building the educational content of the training course based on an integrated approach.