An integrated genomic analysis on miRNAs and SNPs associated with vitiligo to reveal potential drug candidates

Rahman, Razia; Hasija, Yasha

doi:10.24870/cjb.2017-a32

Cited by 1 publication

(1 citation statement)

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“…Many studies have demonstrated the crucial role of miRNAs on the development, proliferation, and survival of cells, including the immune cells and melanocytes 3 , 12 , 13 , 18 . Deregulation of miRNAs was the underlying pathology in many inflammatory skin disorders such as atopic dermatitis, allergic contact dermatitis, and psoriasis 19 .…”

Section: Introductionmentioning

confidence: 99%

Investigating melanogenesis-related microRNAs as disease biomarkers in vitiligo

Abdallah

Abdelhamid

Mohammed

et al. 2022

Sci Rep

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Vitiligo is considered a disabling disease that affects physical, social, psychological, and occupational aspects of an individual's quality of life. The search for non-invasive and reliable biomarkers for vitiligo's early diagnosis, prognosis, and treatment prediction is under intensive investigation. There is currently an emerging interest in employing miRNAs as biomarkers to predict vitiligo diagnosis and prognosis, inspired by the well-preserved nature of miRNAs in serum or plasma. In the current study, we assessed a panel of 20 melanogenesis pathway-related microRNAs (miRNAs) using quantitative real-time PCR technique in 85 non-segmental vitiligo (NSV) patients compared to 85 normal controls followed by function and pathway enrichment analysis for the miRNAs with significant results. Twelve out of the 20 circulating miRNAs showed significantly higher expression levels in vitiligo patients relative to controls where miR-423 show the highest expression level followed by miR-182, miR-106a, miR-23b, miR-9, miR-124, miR-130a, miR-203a, miR-181, miR-152, and miR-320a. While six miRNAs (miR-224, miR-148a, miR-137, and miR-7, miR-148b, miR-145, miR-374b, and miR-196b) didn’t show significant expression level. The analysis of the receiver operating curve indicated that miR-423, miR-106a, and miR-182 were outstanding biomarkers with the highest areas under the curve in vitiligo. This study is the first Egyptian study to investigate a panel of miRNAs expression profile in the plasma of patients with NSV. Our results suggest that specific circulating miRNAs signature might be implicated in vitiligo pathogenesis and could potentially be used as biomarkers in vitiligo.

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