An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers

Uludag, Yildiz; Narter, Fehmi; Sağlam, Erkin; Kokturk, Guzin; Gok, M.; Akgün, Mete; Barut, Serkan; Budak, Sinan

doi:10.1007/s00216-016-9879-z

Cited by 50 publications

(27 citation statements)

References 30 publications

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“…Finally, we want to highlight a work in which the authors described an integrated and fully automated lab‐on‐a‐chip‐based biosensor device prototype (MiSens) for point‐of‐care cancer biomarker testing . This lab‐on‐a‐chip system uses a silicon oxide microchip with gold working electrodes.…”

Section: Ed Based On Nanomaterials In Microfluidicsmentioning

confidence: 99%

Electrochemical detection based on nanomaterials in CE and microfluidic systems

2018

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Electrochemical detection has a great potential in microfluidic systems due to its easy miniaturization without losing analytical performance. In addition, the use of nanomaterials in electroanalysis improves sensitivity, selectivity, and reproducibility. The topic of this review is the use of nanomaterials (nanoparticles, nanotubes, graphene) in electrochemical detection for capillary electrophoresis and microfluidic systems (microchips and paper based analytical devices). This review covers from 2015 up to now and it is a continuation of our previous review, also published in Electrophoresis journal. The following aspects of the surveyed articles are mainly addressed: type of nanomaterial, protocol of working electrode preparation (composite, drop casting and others), advantages of nanomaterial employment and application field (clinical, food, environmental and home security). The use of nanomaterials is still an interesting approach to improve the analytical performance of electrochemical detection based on microfluidic devices. Along the review, readers will find new protocols for working electrode modification, new carbon nanomaterials and promising applications in the aforementioned fields.

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Section: Ed Based On Nanomaterials In Microfluidicsmentioning

confidence: 99%

Electrochemical detection based on nanomaterials in CE and microfluidic systems

2018

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“…The field of integrated microfluidic biomarker analysis has been growing rapidly. Just in recent years, new microfluidic platforms for biomarker analysis have emerged with capabilities for colorimetric or electrochemical assays , ELISA , and other biosensors . However, a common disadvantage of most of these studies is that they were only capable of analyzing a single analyte per device.…”

Section: Introductionmentioning

confidence: 99%

Microchip electrophoresis separation of a panel of preterm birth biomarkers

Nielsen

Sonker

et al. 2018

Electrophoresis

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Preterm birth (PTB) is responsible for over one million infant deaths annually worldwide. Often, the first and only indication of PTB risk is the onset of early labor. Thus, there is an urgent need for an early PTB risk diagnostic that is inexpensive, reliable, and robust. Here, we describe the development of a microchip electrophoresis (μCE) method for separating a mixture of six PTB protein and peptide biomarkers present in maternal blood serum. μCE devices were photografted with a poly(ethylene glycol) diacrylate surface coating to regulate EOF and reduce nonspecific analyte adsorption. Separation conditions including buffer pH, buffer concentration, and applied electric field were varied to improve biomarker peak resolution while minimizing deleterious effects like Joule heating. In this way, it was possible to separate six PTB biomarkers, the first μCE separation of this biomarker panel. LODs were also measured for each of the six PTB biomarkers. In the future, this μCE separation can be integrated with upstream maternal blood serum sample preparation steps to yield a complete PTB risk diagnosis microdevice.

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“…Currently, most diagnostic tests done in centralized laboratories and hospitals. By using expensive equipment that requires highly trained staff, the use of biosensors has facilitated diagnostic technologies, so that work with it done by patients themselves or by medical staff [8][9][10][11].…”

Section: Cancer and Biosensormentioning

confidence: 99%

Investigating the Relationship between New Diagnostic Technology and Information Technology in Diagnosing Cancer: Focusing on Breast Cancer

Farzan

Nafissi

Foroghi

et al. 2019

JPRI

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Introduction: The use of computer-assisted diagnostic tools has increased dramatically in various fields of medicine, especially cancer. It is essential and inevitable to use these tools, especially when there is a need to process large volumes of data, but new diagnostic methods was based on the use of Nano-sensors that have many advantages and they can be used to diagnose breast cancer, one of the most common neoplastic malignancies in the world. The study aims to investigate the relationship between new diagnostic methods and information technology in cancer diagnosis by categorizing research topics and important known aspects of cancer related illness from 1984 to 2017. Methods: The evaluation conducted in March 2018 and used to access the articles on diagnostic and therapeutic methods from the PubMed, Medline, and Cochran library, WHO, Iranmedex and PsycINFO databases. Results: The findings of this study in two sections of cancer and biological sensors show that biomarkers detect disease, and health information technology is expanding and innovating new methods. This can play an important role in managing chronic diseases such as cancer. Conclusion: Primal diagnosis, reducing the time to diagnose and improving the quality of care during treatment, is one of the health’s information technology (IT) benefits of diagnosing cancer. In general, the results this study indicate that the use of information technology to increase the speed of effective therapeutic stages. Resulting in general health, as well as the relationship of information technology with diagnostic and therapeutic methods in our country can greatly increase the level of health and well-being and development, and create a new way of linking information technology and new diagnostic methods to cancer.

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An integrated lab-on-a-chip-based electrochemical biosensor for rapid and sensitive detection of cancer biomarkers

Cited by 50 publications

References 30 publications

Electrochemical detection based on nanomaterials in CE and microfluidic systems

Electrochemical detection based on nanomaterials in CE and microfluidic systems

Microchip electrophoresis separation of a panel of preterm birth biomarkers

Investigating the Relationship between New Diagnostic Technology and Information Technology in Diagnosing Cancer: Focusing on Breast Cancer

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