An integrated planar magnetic micropump

Ni, Junhui; Wang, Bin; Chang, Stanley; Lin, Qiao

doi:10.1016/j.mee.2013.11.014

Cited by 40 publications

(17 citation statements)

References 33 publications

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“…Externally-powered micropumps (e.g., piezoelectric micropumps [6,7], syringe pump [8,9,10], thermopneumatic micropump [11], magnetic micropump [12], and acoustic micropump [13,14]) use off-chip power such as electricity, mechanics, magnetism, and acoustic to drive the flow of microfluidic. Benefiting from the stability of the external components and control system, these micropumps can precisely control the speed of the microfluidic.…”

Section: Introductionmentioning

confidence: 99%

A Novel Self-Activated Mechanism for Stable Liquid Transportation Capable of Continuous-Flow and Real-time Microfluidic PCRs

Shi

et al. 2019

Micromachines

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The self-activated micropump capable of velocity-stable transport for both single-phased plug and double-phased droplet through long flow distance inside 3D microchannel is one dream of microfluidic scientists. While several types of passive micropumps have been developed based on different actuation mechanisms, until today, it is still one bottleneck to realize such a satisfied self-activated micropump for the stable delivery of both single and double-phased liquid inside long microchannel (e.g., several meters), due to the lack of innovative mechanism in previous methods. To solve this problem, in this article, we propose a new self-activated pumping mechanism. Herein, an end-opened gas-impermeable quartz capillary is utilized for passive transport. Mechanism of this micropump is systemically studied by both the mathematical modeling and the experimental verifications. Based on the flow assays, it totally confirmed a different pumping principle in this paper, as compared with our previous works. The R 2 value of the overall flow rates inside the 3D microchannel is confirmed as high as 0.999, which is much more homogeneous than other passive pumping formats. Finally, this novel micropump is applied to continuous-flow real-time PCRs (both plug-type and microdroplet-type), with the amplification efficiency reaching 91.5% of the commercial PCR cycler instrument.

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Section: Introductionmentioning

confidence: 99%

A Novel Self-Activated Mechanism for Stable Liquid Transportation Capable of Continuous-Flow and Real-time Microfluidic PCRs

Shi

et al. 2019

Micromachines

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“…A thin sheet membrane is considered to be the key functional component in a mechanically driven micropump system, especially in microvalve [1][2][3][4][5][6] and valveless [7,8] micropump family. The external force acting on the membrane sheet pulls up or down the diaphragm to allow the fluid to move inside the channel.…”

Section: Introductionmentioning

confidence: 99%

Characteristic of Thin Sheet Membrane for a Mechanical Driven Micropump System

Rusli

Leow

Chee

et al. 2019

IJIE

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This paper demonstrates the characteristic of a thin sheet membrane for a mechanical driven micropump system by using a spin coater technique. The moving diaphragm for the micropump system was made from a PDMS polymer material. A plastic lidded dish with a diameter of 100 mm and height of 15 mm was used as a mould for this study. There were three variables that influence the membrane thickness formation during the spin coating process, which are the polymer weight, spin speed and the spinning time. It was observed that the final parameters to fabricate a thin sheet membrane are 2.5 g of PDMS polymer weight, 500 rpm of spinning speed and 180 s of spin time to yield a 314.82 ± 3.6556 µm thin membrane. This characteristic study is foresee could serve as a design guideline to fabricate a thin sheet membrane for a mechanical driven micropump system by using a petri dish as an alternative to a silicon wafer.

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“…These obstacles were already evident in an early phase of micropump research, which lead to the combination and integration of microfluidic flow sensors in the relevant range of nL/min to mL/min. Various flow sensor principles have since been established and used for combination with micropumps: thermal anemometers [ 21 , 22 , 23 ], differential pressure sensing [ 24 , 25 , 26 , 27 ], time-of-flight pressure sensing [ 28 ], ultrasonic transducers [ 29 ], optical [ 27 , 30 , 31 ] or capacitive [ 32 ] flank monitoring, capacitive [ 33 ] or impedance based [ 34 ] volume monitoring, Coriolis force [ 35 ], hotwire [ 36 ] and fluid drag force on cantilevers [ 37 , 38 ]. The flow monitoring methods were in part used to investigate micropump behavior and in part connected to a control unit in order to build closed-loop controlled systems to improve dosing accuracy.…”

Section: Introductionmentioning

confidence: 99%

The Combination of Micro Diaphragm Pumps and Flow Sensors for Single Stroke Based Liquid Flow Control

Jenke

Rubio

Kibler

et al. 2017

Sensors

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With the combination of micropumps and flow sensors, highly accurate and secure closed-loop controlled micro dosing systems for liquids are possible. Implementing a single stroke based control mode with piezoelectrically driven micro diaphragm pumps can provide a solution for dosing of volumes down to nanoliters or variable average flow rates in the range of nL/min to μL/min. However, sensor technologies feature a yet undetermined accuracy for measuring highly pulsatile micropump flow. Two miniaturizable in-line sensor types providing electrical readout—differential pressure based flow sensors and thermal calorimetric flow sensors—are evaluated for their suitability of combining them with mircopumps. Single stroke based calibration of the sensors was carried out with a new method, comparing displacement volumes and sensor flow volumes. Limitations of accuracy and performance for single stroke based flow control are described. Results showed that besides particle robustness of sensors, controlling resistive and capacitive damping are key aspects for setting up reproducible and reliable liquid dosing systems. Depending on the required average flow or defined volume, dosing systems with an accuracy of better than 5% for the differential pressure based sensor and better than 6.5% for the thermal calorimeter were achieved.

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An integrated planar magnetic micropump

Cited by 40 publications

References 33 publications

A Novel Self-Activated Mechanism for Stable Liquid Transportation Capable of Continuous-Flow and Real-time Microfluidic PCRs

A Novel Self-Activated Mechanism for Stable Liquid Transportation Capable of Continuous-Flow and Real-time Microfluidic PCRs

Characteristic of Thin Sheet Membrane for a Mechanical Driven Micropump System

The Combination of Micro Diaphragm Pumps and Flow Sensors for Single Stroke Based Liquid Flow Control

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