An Integrated Platform for Bio-Analysis and Drug Delivery

Amer, Sabri; Badawy, W.

doi:10.2174/1389201053167220

Cited by 21 publications

(13 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The versatility of using polymers in combination with MEMS technology has led to several innovative ideas of loading novel drug delivery carriers for controlled release applications [112–114]. Most of these innovative carriers load and release drugs using responsive polymeric hydrogels, degradable polymer coatings, dissolvable thin metal films, or capillary action.…”

Section: Loading Of Novel Micro- and Nanoscale Oral Drug Delivery mentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

View full text Add to dashboard Cite

The oral route of drug administration is most preferred due to its ease of use, low cost, and high patient compliance. However, the oral uptake of many small molecule drugs and biotherapeutics is limited by various physiological barriers, and, as a result, drugs suffer from issues with low solubility, low permeability, and degradation following oral administration. The flexibility of micro- and nanofabrication techniques has been used to create drug delivery platforms designed to address these barriers to oral drug uptake. Specifically, micro/nanofabricated devices have been designed with planar, asymmetric geometries to promote device adhesion and unidirectional drug release toward epithelial tissue, thereby prolonging drug exposure and increasing drug permeation. Furthermore, surface functionalization, nanotopography, responsive drug release, motion-based responses, and permeation enhancers have been incorporated into such platforms to further enhance drug uptake. This review will outline the application of micro/nanotechnology to specifically address the physiological barriers to oral drug delivery and highlight technologies that may be incorporated into these oral drug delivery systems to further enhance drug uptake.

show abstract

Section: Loading Of Novel Micro- and Nanoscale Oral Drug Delivery mentioning

confidence: 99%

Micro/nanofabricated platforms for oral drug delivery

Fox

Kim

et al. 2015

Journal of Controlled Release

View full text Add to dashboard Cite

show abstract

“…Owing to their flexibility and programmability, in comparison with polymer-based DDS they increase the level of control over drug release, which can be triggered, pulsed and switched on and off. Moreover, their manufacturing based on batch-processing techniques typical of microelectronics industry leads to greater device uniformity and reproducibility (20,21).…”

Section: The Tablet Of the Future: Microfabricated Devices As Oral Drmentioning

confidence: 99%

Novel Platforms for Oral Drug Delivery

et al. 2009

View full text Add to dashboard Cite

The aim of this review is to provide the reader general and inspiring prospects on recent and promising fields of innovation in oral drug delivery. Nowadays, inventive drug delivery systems vary from geometrically modified and modular matrices, more close to "classic" pharmaceutical manufacturing processes, to futuristic bio micro-electro-mechanical systems (bioMEMS), based on manufacturing techniques borrowed from electronics and other fields. In these technologies new materials and creative solutions are essential designing intelligent drug delivery systems able to release the required drug at the proper body location with the correct release rate. In particular, oral drug delivery systems of the future are expected to have a significant impact on the treatment of diseases, such as AIDS, cancer, malaria, diabetes requiring complex and multi-drug therapies, as well as on the life of patients, whose age and/or health status make necessary a multiple pharmacological approach.

show abstract

“…These novel ferroelectric nano-materials are very promising for nanobiotechnology, nanobiomedicine, bio-and microelectronics, and as a prospective component of various nanocomposites and "intellectual" templates with "smart surface" properties. Having high compatibility with many organic and biological molecules and tissues they possess appropriate acoustic and piezoelectric properties [22][23][24]. One promising idea is to use actuators made from biocompatible polyvinylidene fluoride (PVDF) piezoelectric materials [25] since they demonstrate high surface charge -polarization of PVDF / P(VDF-TrFE) and its switching under specific external influences, such as changes of an external electric field.…”

Section: Introductionmentioning

confidence: 99%

Анализ Вычислительных И Экспериментальных Исследований Переключения Поляризации В ПВДФ И П (Вдф-ТрФЭ) Сегнетоэлектрических Пленках На Наноуровне

Bystrov¹

2015

Math.Biol.Bioinf.

View full text Add to dashboard Cite

Abstract. In this paper, molecular models are used to investigate and analyze the polarization switching in the polyvinylidene fluoride (PVDF) and poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) Langmuir-Blodgett (LB) nanofilms, in comparison with the experimental data at the nanoscale. Quantum-mechanical calculations and modeling, as well as molecular dynamics (MD) simulations based on semi-empirical quantum-chemical methods (such as PM3), show that the energy of the studied PVDF and P (VDF-TrFE) molecular structures, and their polarization switching proceed by the intrinsic homogeneous switching mechanism in the framework of the phenomenological theory of Landau-Ginzburg-Devonshire (LGD) in the linear approximation at low values of the electric field. The magnitude of the resulting critical coercive field is within the EC ~ 0.5 ... 2.5 GV/m, which is consistent with experimental data. It is also found that the uniform polarization switching mechanism of the polymer chains PVDF and P (VDF-TrFE) is due to the quantum properties of the molecular orbitals of the electron subsystem. This is clearly seen in both the polarization hysteresis loops, and the total energy changes. In this case, the turnover chain time, obtained by molecular dynamics within semi-empirical quantum-chemical PM3 approach in a limited Hartree-Fock approximation, when approaching this critical point, increases sharply, tending to infinity, which corresponds to the theory of LGD. Otherwise, at the high values of the applied electric field the polarization switching correspond to the extrinsic domain mechanism in the frame of the microscopic KolmogorovAvrami-Ishibashi (KAI) theory, describing bulk ferroelectric crystals and thick films. The performed analysis of computational and experimental data allows us to estimate the critical sizes of the possible transition region approximately on the order of 10 nm between intrinsic homogeneous and extrinsic domain switching mechanisms.

show abstract

An Integrated Platform for Bio-Analysis and Drug Delivery

Cited by 21 publications

References 75 publications

Micro/nanofabricated platforms for oral drug delivery

Micro/nanofabricated platforms for oral drug delivery

Novel Platforms for Oral Drug Delivery

Анализ Вычислительных И Экспериментальных Исследований Переключения Поляризации В ПВДФ И П (Вдф-ТрФЭ) Сегнетоэлектрических Пленках На Наноуровне

Contact Info

Product

Resources

About