2022
DOI: 10.1186/s12967-022-03266-1
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An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signature

Abstract: Background Emerging evidences have indicated that the aberrant liquid–liquid phase separation (LLPS) leads to the dysfunction of biomolecular condensates, thereby contributing to the tumorigenesis and progression. Nevertheless, it remains unclear whether or how the LLPS of specific molecules affects the prognosis and tumor immune microenvironment (TIME) of patients with lower-grade glioma (LGG). Methods We integrated the transcriptome information o… Show more

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Cited by 9 publications
(8 citation statements)
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“…The prognosis for patients with glioma remains dismal due to intratumoral heterogeneity ( Jan et al, 2010 ). Accumulating evidence revealed a prominent association between different molecular subtypes and clinical outcomes in glioma patients ( Li et al, 2022 ; Zheng et al, 2022 ). And several studies showed that costimulatory molecules took a great part in initiating anti-tumor immune responses ( Zhang et al, 2020 ), but there was little literature focused on the correlation between costimulatory molecules and stratification of patients with glioma.…”
Section: Discussionmentioning
confidence: 99%
“…The prognosis for patients with glioma remains dismal due to intratumoral heterogeneity ( Jan et al, 2010 ). Accumulating evidence revealed a prominent association between different molecular subtypes and clinical outcomes in glioma patients ( Li et al, 2022 ; Zheng et al, 2022 ). And several studies showed that costimulatory molecules took a great part in initiating anti-tumor immune responses ( Zhang et al, 2020 ), but there was little literature focused on the correlation between costimulatory molecules and stratification of patients with glioma.…”
Section: Discussionmentioning
confidence: 99%
“…C-index was calculated to evaluate the consistency of real and predicting survival outcomes. To further verify the performance of CCSPI, we compared different risk systems from other studies ( Supplementary Table S2 ) measured by AUCs and C-index ( Zhang et al, 2020 ; Luo et al, 2021 ; Zhao et al, 2021 ; Zhou et al, 2021 ; Wu et al, 2022 ; Zheng et al, 2022 ) in the CGGA validation cohort.…”
Section: Methodsmentioning
confidence: 99%
“…More and more studies have demonstrated the relevance of LLPS to tumor development and progression. [21][22][23][24] LLPS-related genes (LRGs) have been shown to signi cantly predict the prognosis of ovarian cancers, [25] malignant tumors of the digestive system,[26] and low-grade gliomas [27]. These ndings provide a useful reference for precise treatment of tumor.…”
Section: Introductionmentioning
confidence: 99%