An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus

Kurt‐Kızıldoğan, Aslıhan; Çelik, Gözde; Ünsaldı, Eser; Özcan, Servet; Ayaz-Güner, Şerife; Özcengiz, Gülay

doi:10.1007/s00253-022-12098-4

Cited by 5 publications

(1 citation statement)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nisin, as an efficient, non-toxic, safe, and non-side-effect-inducing natural food preservative additive, is added to dairy products, fermented beverages, canned foods, and meat products to control the growth of pathogenic microorganisms such as Staphylococcus aureus and Listeria monocytogenes, thereby extending the shelf life of foods [5]. Microorganisms are also used as biosynthetic agents in the pharmaceutical industry; for instance, clavulanic acid (CA), an important secondary metabolite produced by Streptomyces clavuligerus of the Actinobacillus family, is used clinically for the treatment of infectious diseases [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of Soy Protein Products on Growth and Metabolism of Bacillus subtilis, Streptococcus lactis, and Streptomyces clavuligerus

Wen,

Hu,

Gao

et al. 2024

Foods

View full text Add to dashboard Cite

Microbial nitrogen sources are promising, and soy protein as a plant-based nitrogen source has absolute advantages in creating microbial culture medium in terms of renewability, eco-friendliness, and greater safety. Soy protein is rich in variety due to different extraction technologies and significantly different in the cell growth and metabolism of microorganisms as nitrogen source. Therefore, different soy proteins (soy meal powder, SMP; soy peptone, SP; soy protein concentrate, SPC; soy protein isolate, SPI; and soy protein hydrolysate, SPH) were used as nitrogen sources to culture Bacillus subtilis, Streptococcus lactis, and Streptomyces clavuligerus to evaluate the suitable soy nitrogen sources of the above strains. The results showed that B. subtilis had the highest bacteria density in SMP medium; S. lactis had the highest bacteria density in SPI medium; and S. clavuligerus had the highest PMV in SPI medium. Nattokinase activity was the highest in SP medium; the bacteriostatic effect of nisin was the best in SPI medium; and the clavulanic acid concentration was the highest in SMP medium. Based on analyzing the correlation between the nutritional composition and growth metabolism of the strains, the results indicated that the protein content and amino acid composition were the key factors influencing the cell growth and metabolism of the strains. These findings present a new, high-value application opportunity for soybean protein.

show abstract

Section: Introductionmentioning

confidence: 99%