An integrative review of skin assessment tools used to evaluate skin injury related to external beam radiation therapy

Baines, Carol; McGuiness, William; O’Rourke, Geraldine

doi:10.1111/jocn.13430

Cited by 14 publications

(11 citation statements)

References 47 publications

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“…The Radiation Therapy Oncology Group's (RTOG) acute radiation morbidity scoring criteria for skin will be used as the primary outcome of the study [17]. The RTOG scale is widely used as a measure for radiation injury in the skin [17,18].…”

Section: Primary Outcomesmentioning

confidence: 99%

“…Based on the study used for the RTOG sample size calculation, we assume that the erythema will be most pronounced 2 weeks after conclusion of radiation therapy. We also assume that melatonin applied twice daily in a 2.5% cream, will provide a dose comparable to the 12.5% used in the study evaluating ultraviolet radiation [18], due to a deposition effect in the skin [24]. Furthermore, we have been informed by the authors of the previous study utilizing the 12.5% cream that the cream was not homogenous, and there were small granules of undissolved melatonin in the 2.5%, 5%, and 12.5% creams used.…”

Section: Sample Size Calculationsmentioning

confidence: 99%

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MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer

Zetner¹,

Kamby²,

Mahmood³

et al. 2019

Melatonin Res.

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Radiation dermatitis following radiation therapy in the treatment of early breast cancer can lead to discontinuation or prolongation of treatment and an impaired quality of life. Melatonin has been demonstrated to protect against radiation injury. The aim of this study is to investigate whether melatonin can protect against radiation dermatitis when applied topically in women receiving radiation therapy for early breast cancer. This study will be a randomized, placebo-controlled, double-blind controlled trial. Patients will apply the melatonin or placebo preparation topically twice daily for the duration of their radiation therapy. Our objective outcomes will be the Radiation Therapy Oncology Group’s acute radiation morbidity scoring criteria for skin, image analysis of clinical photographs, and use of steroid cream for radiation dermatitis. Subjective outcomes will be quality of life questionnaires developed by the European Organisation for Research and Treatment of Cancer. Outcomes will be measured throughout the five weeks of radiation treatment and be followed up for another three weeks. According to sample-size calculations and inclusion schedule, we intend to include a total of 80 evaluable patients. We will analyze the primary outcomes using parametric and non-parametric tests where applicable. Secondary outcomes will be analyzed by a mixed linear model. Most patients with breast cancer who undergo radiation therapy will develop radiation dermatitis as a result of the therapy. Should our intervention provide better outcomes, many patients could obtain a better quality of life. We expect topical melatonin treatment to have little or no adverse effects, to be easy to apply, and not to interfere with the anti-tumor efficacy of the radiation therapy.

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Section: Primary Outcomesmentioning

confidence: 99%

Section: Sample Size Calculationsmentioning

confidence: 99%

MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer

Zetner¹,

Kamby²,

Mahmood³

et al. 2019

Melatonin Res.

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“…Several limitations of current treatments for bone diseases include: wide excisions of tissue [13] (in cases using amputation surgery), low targeting efficiency and adverse effects on other organs and tissues (in cases using chemotherapy and radiation therapy) [14], short plasma half-life and poor physicochemical stability in biodistribution (in cases using biomacromolecular drugs), and insufficient bone graft sources and risk of infection and host immune responses (in cases using bone grafts) [15]. …”

Section: Introductionmentioning

confidence: 99%

Development of nanomaterials for bone-targeted drug delivery

Cheng

Chawla

Yang

et al. 2017

Drug Discovery Today

117

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Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.

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“…Entre as diferentes abordagens no manejo da exposição da pele a radiação existem as lavagens práticas com água e sabonetes, curativos ou ainda filmes anti-inflamatórios. É recomendada a higiene completa e a utilização de cremes com lanolina aumentando a umidade e a maleabilidade da pele[4,20]. Estudos que elucidam a ação fibrótica da pele após a exposição a radiação ainda não foram esgotados, recentemente pesquisas estão sendo direcionadas ao entendimento das alterações moleculares adjacentes a area afetada.Ao contrário dos sistemas anteriores o manejo com a exposição da pele se dá de forma direta, atualmente as abordagens na atenção do indivíduo exposto a radiação através da pele utiliza de lavagens práticas, o uso de curativos e anti-inflamatórios.…”

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“…Estudos vêm crescendo na elucidação da ação fibrótica da pele e ao conhecimento das mudanças a níveis moleculares de áreas circundantes do tecido afetado. Essas mudanças desencadeiam reações intracelulares e efeitos exógenos[20]. A radioterapia é um componente preditor no tratamento de diversos tipos de câncer, é preciso planejar sobre os efeitos colaterais do manejo com a terapia.…”

unclassified

Análise de modelos atuais para os efeitos biológicos e suas consequências - Uma revisão integrativa

Freitas

Claus

Diniz

et al. 2019

BJHR

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An integrative review of skin assessment tools used to evaluate skin injury related to external beam radiation therapy

Cited by 14 publications

References 47 publications

MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer

MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer

Development of nanomaterials for bone-targeted drug delivery

Análise de modelos atuais para os efeitos biológicos e suas consequências - Uma revisão integrativa

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