2019
DOI: 10.1016/j.toxlet.2019.08.004
|View full text |Cite
|
Sign up to set email alerts
|

An inter-laboratory in vitro assessment of cigarettes and next generation nicotine delivery products

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
12
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
9

Relationship

4
5

Authors

Journals

citations
Cited by 14 publications
(12 citation statements)
references
References 48 publications
0
12
0
Order By: Relevance
“…Present studies suggest that HnB tobacco products have the potential to be a reduced risk product for public health compared to traditional cigarettes, especially when indirectly considering the potential effects on the chronic diseases which are traditionally linked to traditional cigarette use (i.e., CVDs, cancer, COPD) [25,31]. Nonetheless, further studies are needed to determine whether this potential is likely to be realized.…”
Section: Conclusion and Further Researchmentioning
confidence: 92%
“…Present studies suggest that HnB tobacco products have the potential to be a reduced risk product for public health compared to traditional cigarettes, especially when indirectly considering the potential effects on the chronic diseases which are traditionally linked to traditional cigarette use (i.e., CVDs, cancer, COPD) [25,31]. Nonetheless, further studies are needed to determine whether this potential is likely to be realized.…”
Section: Conclusion and Further Researchmentioning
confidence: 92%
“…In a previous study using diluted aerosols (Anthérieu et al, 2017), we have tested the Lounge model with different e-liquids (with or without nicotine, flavoured or unflavoured) and demonstrated that none of the aerosols induced cytotoxicity in BEAS-B cell line up to an exposure of 576 puffs. Today, few in vitro studies have compared the relative cytotoxicity of HTP aerosols with both cigarette smoke and e-cig vapours, and most of these assays have been performed using submersed cultures exposed to aerosol extracts (Ito et al, 2019;Munakata et al, 2018;Sohal et al, 2019). ALI exposures provide a more pertinent approach to perform toxicological studies related to inhalation of emerging e-cigs or novel tobacco products (Johnson et al, 2009).…”
Section: Cell Viabilitymentioning
confidence: 99%
“…30 The usefulness of a 2D-culture system for detecting CSinduced oxidative stress responses was demonstrated by a previous interlaboratory study in which the exposure of 2D-culture systems using different lung cell lines (i.e., H292 and BEAS-2B cells) to total particulate matter from CS induced intracellular oxidative stress responses with interlaboratory reproducibility. 31 That study also exposed 2D-culture systems to the aerosol-collected masses of two tobacco heating products and an e-cigarette, and the results indicated that no oxidative stress responses were induced. Unlike this previous study, we used AqE of vapor from our proprietary novel tobacco product (i.e., NTV) for exposure instead of aerosol-collected mass because the use of AqE for exposure enables the application of higher concentrations of vapor exposure compared with the use of aerosolcollected mass.…”
Section: Discussionmentioning
confidence: 90%