An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation

Bouchard-Mercier, Annie; Rudkowska, Iwona; Lemieux, Simone; Couture, Patrick; Vohl, Marie‐Claude

doi:10.1007/s12263-014-0395-5

Cited by 7 publications

(11 citation statements)

References 35 publications

(46 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is currently unclear what the actual association with type 2 diabetes is for the GCKR (rs780094) derived allele. In a study of the other SNP, GCKR (rs741038), for which the ancestral allele was associated with both hypertriglyceridemia and low HDL in our study, other researchers showed the greatest decrease in TG in over weight subjects (Canadians; n= 208; 96 male, 112 Female; age 30.82 ± 8.66; BMI 27.84 ± 3.73) with the derived allele of GCKR (rs741038) after fish oil supplementation when on a high carbohydrate diet [28] . These data suggest that those with the ancestral allele may not benefit from n-3 fish oil as much as those with the derived allele.…”

Section: Discussionmentioning

confidence: 61%

“…A higher dietary intake of omega-3 polyunsaturated fatty acids (PUFA) was associated with a detrimental increase in plasma APOC3 in those individuals with the CC polymorphism APOC3 (rs2854116) [27] . However, fish oil supplementation was found to lower triglyceride (TG) levels in human subjects homozygous for GCKR (rs741038) [28] . Genetic polymorphisms exacerbated by dietary factors may play a role in the pathogenesis of NAFLD in all populations or perhaps only individuals at risk for obesity or type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…We focused on 8 SNPs in 6 genes for which published feed studies were available [14,19–28] . A second objective was to determine the associations of these genes with selected indicators for NAFLD (AST, ALT), for three indicators of metabolic syndrome which were overweight/obesity (BMI), insulin resistance (high triglyceride plus low HDL levels) and hypertension (SBP, DBP, MAP), for type 2 diabetes (HbA1c) and for cardiovascular disease (higher than optimal levels of LDL and total cholesterol) in a specific NM population.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

NAFLD Susceptibility Genes and Their Association with Type 2 Diabetes and Obesity in a New Mexico Population

Garner¹,

Conn²,

Cohen³

et al. 2015

JDO

View full text Add to dashboard Cite

Objective Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) that increase the risk of developing non-alcoholic fatty liver disease (NAFLD). One purpose of this study was to determine the frequencies of NAFLD susceptibility SNPs in a non-Hispanic white and Hispanic population who attended a clinic in northeast Albuquerque, NM. Another goal was to determine associations with selected indicators in this New Mexican population. Methods This cohort study involving 168 volunteer subjects in the NM population (88 non-Hispanic whites, 63 Hispanics, 4 Native Americans, 11 Asian Americans, 2 unreported ethnicity). Eight SNPs within 6 NAFLD susceptibility genes including PNPLA3 (rs738409), LYPLAL1 (rs12137855), APOC3 (rs2854116, rs2854117), GCKR (rs780094, rs741038), FABP2 (rs1799883), PEMT (rs7946) were analyzed by genotyping using the TaqMan genotyping assay (Applied Biosystems, Foster City, CA). Statistical analyses were carried out using statistical package SAS 9.3. Results The NAFLD allele frequencies were similar in non-Hispanic whites and Hispanics except for PNPLA3 (rs738409), FABP2 (rs1799883), and PEMT (rs7946). Eight SNPs in 5 NAFLD susceptibility genes were significantly associated OR marginally associated with selected indicators for NAFLD, metabolic syndrome, overweight, obesity, insulin resistance, type 2 diabetes, hypertension, dyslipidemia. No SNPs were significantly associated with the same indicator in both the non-Hispanic white and Hispanic groups. Conclusions In this population of non-Hispanic whites and Hispanics, there were only heterozygotes for the APOC3 derived alle le whereas for all other genes tested, both heterozygotes and homozygotes were found. Associations of alleles with indicators of chronic disease were different in non-Hispanic whites compared to Hispanics.

show abstract

Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

NAFLD Susceptibility Genes and Their Association with Type 2 Diabetes and Obesity in a New Mexico Population

Garner¹,

Conn²,

Cohen³

et al. 2015

JDO

View full text Add to dashboard Cite

show abstract

“…In addition, dopamine, which is synthesized from the AAs, phenyalanine and tyrosine, was also associated with obesity in the US women. An elevated BCAA and AA profile in obese individuals has previously been associated with a Westernized diet, typically characterized by high levels of protein and fat intake (Newgard et al 2009; Bouchard-Mercier et al 2014). Ghanaian women, consumed significantly less protein and fat than their US and SA counterparts, which could partly account for their lower AA levels.…”

Section: Discussionmentioning

confidence: 99%

Obesity-related metabolite profiles of black women spanning the epidemiologic transition

et al. 2016

View full text Add to dashboard Cite

In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.

show abstract

“…They have also been shown to interact with fatty acid desaturase (FADS) variants to affect low-density lipoprotein (LDL) cholesterol concentrations and obesity phenotype (85,86). Additionally, carbohydrate intake has also been reported to interact with glucokinase genetic variation to affect plasma triglycerides (57). …”

Section: Introductionmentioning

confidence: 99%

Nutritional Genomics of Cardiovascular Disease

Voruganti

2018

Curr Genet Med Rep

View full text Add to dashboard Cite

Purpose Cardiovascular disease (CVD) is the leading cause of death in the United States and globally. There is significant evidence implicating genetic and dietary factors in the development and progression of CVD and its risk factors. Nutritional genomics is a comparatively new field of science that focuses on the relationship of individual genetic variation with response to nutrition. The purpose of this review is to summarize recent progress, in the field of nutritional genomics as it relates to cardiovascular disease. Recent findings Evidence from recent studies has shown significant effects of gene-diet interactions on CVD biomarkers and the development and progression of CVD. The cardiovascular effects of gene-nutrient interactions with respect to macronutrients and genes such as FTO, ACE, PPARs, TCF7L2, BDNF, MC4R, APOAs, FADS, etc. have shown consistent results across age groups and populations whereas gene-nutrient interaction effects of other genes have only been limited to specific ages, genders or populations and need to validated and confirmed. Summary The identification of individual genetic variation influencing diet-related CVD risk is important and may inform future nutritional intervention studies. Although there is ample scientific evidence indicating that the genetic susceptibility to CVD can be modified by diet, we are still not at a stage where this information is easily translated into dietary plans. Thus, there is a need for better approaches to achieve precision in dietary data collection and streamline computational approaches for meaningful and effective nutritional interventions.

show abstract

An interaction effect between glucokinase gene variation and carbohydrate intakes modulates the plasma triglyceride response to a fish oil supplementation

Cited by 7 publications

References 35 publications

NAFLD Susceptibility Genes and Their Association with Type 2 Diabetes and Obesity in a New Mexico Population

NAFLD Susceptibility Genes and Their Association with Type 2 Diabetes and Obesity in a New Mexico Population

Obesity-related metabolite profiles of black women spanning the epidemiologic transition

Nutritional Genomics of Cardiovascular Disease

Contact Info

Product

Resources

About