An interesting case of primary squamous cell carcinoma of the colon with synchronous metastatic adenocarcinoma

Rajan, Ruben; Baqar, Ali Riaz; Menon, T. Bhaskara

doi:10.1002/ccr3.127

Cited by 11 publications

(7 citation statements)

References 13 publications

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“…Case two was initially clinically diagnosed as stage 4 SCC and received capecitabine, then radiation with carboplatin and paclitaxel, and lastly three cycles of 5-FU, oxaliplatin, and leucovorins, each with disease progression. Another unique comparison is that both of our patients were much younger than the average reported mean age of 53–60 [ 2 , 13 ].…”

Section: Discussionmentioning

confidence: 97%

Squamous cell carcinoma of the ascending colon: two cases

Abdelqader

Jabaji

Albugeaey

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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Squamous cell carcinoma (SCC) of the colon without known primary source is a rare finding that needs aggressive management. We report two cases of SCC of the colon without any clear extra-colonic source despite extensive workup. In our experience, the clinical course and prognosis are largely dependent on the presence of metastatic disease at diagnosis. The main treatment is surgery, with chemotherapy having less defined role.

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Section: Discussionmentioning

confidence: 97%

Squamous cell carcinoma of the ascending colon: two cases

Abdelqader

Jabaji

Albugeaey

et al. 2017

Journal of Community Hospital Internal Medicine Perspectives

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“…Although the etiology and pathogenesis of SCC are unclear, there have been multiple possible hypotheses regarding the pathophysiology of the SCC. These theories propose that chronic inflammatory bowel disease, inflammation due to infection, mucosal injury, squamous cell differentiation by pluripotent stem cells, or radiation exposure can lead to squamous metaplasia [4,8,9]. Pre-existing adenomas or adenocarcinomas and associated HPV infection have been hypothesized to develop into SCC [10,11].…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus Positive Squamous Cell Carcinoma of the Rectum

Makadia¹,

Patel²,

Abusaada³

2020

Cureus

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Squamous cell carcinoma (SCC) is most commonly seen in the esophagus and anal canal in the gastrointestinal tract. The incidence of SCC of the rectum is infrequent with no clear etiology. There have been limited reported cases of SCC of the rectum caused by human papillomavirus (HPV). Due to the rarity of carcinoma, the management of SCC of the rectum is not standardized. We report a case of a 51-year-old female with an insignificant medical history presenting with hematochezia and weight loss and was found to have HPV-positive SCC of the rectum. This case report emphasizes the importance of work-up, usefulness of HPV testing for high-risk patients, and clinical management of SCC of the rectum.

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“…Frequently reported symptoms include rectal bleeding, abdominal pain, change in bowel habits, weight loss, and bowel obstruction [ 2 ]. In the literature review, we only found three cases describing sigmoid or splenic flexure perforation, but none with cecal perforation [ 7 - 9 ]. Given the unclear underlying mechanism of these malignancies and how infrequently they present, the following criteria have been proposed by Williams et al to diagnose SCC of the colon: (1) no evidence of a primary SCC elsewhere that could be a source of metastatic or direct extension to the bowel, (2) the affected segment of the bowel is not in continuity with a squamous lined fistula, (3) there is no continuity between the tumor and the anal squamous epithelium, and (4) confirmation of SCC by histological analysis [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Cecum Presenting as Spontaneous Perforation

Recinos

Mohapatra

Broder

et al. 2020

Cureus

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Squamous cell carcinoma (SCC) of the colon is an extremely rare condition, and its pathogenesis is not fully understood. Bowel perforation is a very infrequent manifestation of colonic SCC, and only a few cases have been reported in the literature involving sigmoid and splenic flexure perforation. To the best of our knowledge, no cases of ileocecal perforation have been documented in the literature. Here we present a case of cecal SCC that presented with bowel perforation, necessitating emergent surgical intervention. Histopathological examination showed SCC with lymph node metastasis. This case reviews current knowledge and highlights the rare manifestation that these rare tumors can present.

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An interesting case of primary squamous cell carcinoma of the colon with synchronous metastatic adenocarcinoma

Abstract: Key Clinical MessageWe present a case of primary squamous cell carcinoma of the colon with synchronous metastatic adenocarcinoma. This case highlights the poor prognosis of these late presenting cancers. Furthermore, the unusual dual pathology raises questions about its potential etiology.

Cited by 11 publications

References 13 publications

Squamous cell carcinoma of the ascending colon: two cases

Squamous cell carcinoma of the ascending colon: two cases

Human Papillomavirus Positive Squamous Cell Carcinoma of the Rectum

Primary Squamous Cell Carcinoma of the Cecum Presenting as Spontaneous Perforation

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