An interventional implementation project: hand hygiene improvement

Ni, Lei; Wang, Qunmin; Wang, Fang; Ni, Zuowei; Zhang, Sheng; Zhong, Zifeng; Chen, Zuobing

doi:10.21037/atm-20-5480

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…[ 2 ] Although NAFLD is not a severe disease, it can progress from simple steatosis to serious nonalcoholic steatohepatitis and eventually leads to irreversible liver cirrhosis, and even liver carcinoma. [ 3 ] Hence, effective prevention and alleviation of NAFLD is needful.…”

Section: Introductionmentioning

confidence: 99%

α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway

Chen

et al. 2023

Molecular Nutrition Food Res

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ScopeDietary intervention has emerged as a promising strategy for the management of nonalcoholic fatty liver disease (NAFLD). The aim of this study is to investigate the ameliorative effects of the α‐lactalbumin peptide Asp‐Gln‐Trp (DQW) against NAFLD and the underlying mechanism.Methods and resultsThe models of lipid metabolism disorders are established both in HepG2 cells and in C57BL/6J mice. The results demonstrate that DQW activates peroxisome proliferator‐activated receptor α (PPARα) and subsequently ameliorates lipid deposition and oxidative stress in vitro. Interestingly, GW6471 markedly attenuates the modulatory effects of DQW on the PPARα pathway in HepG2 cells. Moreover, results of in vivo experiments indicate that DQW alleviates body weight gain, dyslipidemia, hepatic steatosis, and oxidative stress in high‐fat‐diet (HFD)‐induced NAFLD mice. At the molecular level, DQW activates PPARα, subsequently enhances fatty acid β‐oxidation, and reduces lipogenesis, thereby ameliorating hepatic steatosis. Meanwhile, DQW may ameliorate liver injury and oxidative stress via activating the PPARα/nuclear‐factor erythroid 2 (Nrf2)/heme‐oxygenase 1 (HO‐1) pathway.ConclusionThose results indicate that α‐lactalbumin peptide DQW may be an effective dietary supplement for alleviating NAFLD by alleviating lipid deposition and oxidative stress.

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Section: Introductionmentioning

confidence: 99%

α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway

Chen

et al. 2023

Molecular Nutrition Food Res

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Analysis of Factors Affecting the Behaviour of Medical Personnel in Carrying Out Hand Hygiene

Sari

Winarno

2022

IJOSH

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Introduction: The activities of health workers in carrying out their profession are very risky for nosocomial infections and very high infectious diseases . The Ministry of Health urges every medical personnel to carry out hand hygiene as an effort to minimize the occurrence of nosocomial infections. The purpose of this study was to determine the factors which affect the behaviour of medical personnel in carrying out hand hygiene protocols. Methods: This research was a correlational descriptive research. The population in this study were medical personnel of Kebonsari Public Health Center Surabaya, and the samples were taken using a simple random sampling technique with a total of 63 respondents. The variables in this study were knowledge, attitude, training, commitment, supervision and behaviour. Data collection was carried out using a questionnaire sheet, direct observation and statistical test using a path analysis. Results: The results of simultaneous statistical tests upon knowledge, attitude, training, commitment, and supervision showed that those 5 factors had an effect on hand hygiene behaviour with 45.6% coefficient of determination (R2), and the results of a partial statistical test (t test) on knowledge, training, commitment, and supervision showed a significant effect on hand hygiene behavior of < 0.05, while attitudes had no significant effect on hand hygiene behavior of > 0.05. Conclusion: Knowledge, training, commitment and supervision affected the behaviour of medical personnel in carrying out hand hygiene. These variables, theoretically, contribute to forming good behaviour.Keywords: behavioral factors, hand hygiene, medical personnel

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An interventional implementation project: hand hygiene improvement

Cited by 2 publications

References 25 publications

α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway

α‐Lactalbumin Peptide Asp‐Gln‐Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids‐Treated HepG2 Cells and High‐Fat Diet‐Induced NAFLD Mice by Activating the PPARα Pathway

Analysis of Factors Affecting the Behaviour of Medical Personnel in Carrying Out Hand Hygiene

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