2010
DOI: 10.1038/nature08826
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An intrinsic vasopressin system in the olfactory bulb is involved in social recognition

Abstract: Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released in the brain where they play fundamentally important roles in social behaviours1. In humans, disruptions of these peptide systems have been linked to several neurobehavioural disorders, including Prader-Willi syndrome, affective disord… Show more

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Cited by 195 publications
(245 citation statements)
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“…A transient vasopressin immunoreactivity in the cortex in the first postnatal week of golden hamsters has also been reported (Delville et al, 1994b). Vasopressin neurons are also detected in the locus coeruleus of rats (Caffe and Van Leeuwen, 1983) and have also been detected in the adult rat olfactory bulb (Tobin et al, 2010), but the development of this population is unknown. The genes encoding oxytocin and vasopressin each include a neurophysin, which serves as a carrier protein.…”
Section: Dynamic Developmental Profiles: When and Where Are The Factomentioning
confidence: 93%
“…A transient vasopressin immunoreactivity in the cortex in the first postnatal week of golden hamsters has also been reported (Delville et al, 1994b). Vasopressin neurons are also detected in the locus coeruleus of rats (Caffe and Van Leeuwen, 1983) and have also been detected in the adult rat olfactory bulb (Tobin et al, 2010), but the development of this population is unknown. The genes encoding oxytocin and vasopressin each include a neurophysin, which serves as a carrier protein.…”
Section: Dynamic Developmental Profiles: When and Where Are The Factomentioning
confidence: 93%
“…OT and AVP also shape the neural representation of the partner by building a profile through olfactory cues, which remains stable (69). For rodents, at least, the odor of the partner comes to be associated with a pleasurable and rewarding encounter (70). Zeki (69) suggests that human adaptations of the same essential mechanisms underlie romantic and maternal love.…”
Section: Neuropeptide-dopaminergic Interactionsmentioning
confidence: 99%
“…Both oxytocin and vasopressin are modulators of social behaviour (Caldwell et al 2008, Lee et al 2009, Neumann & Landgraf 2012. Parvocellular oxytocin and vasopressin neurons in the paraventricular nucleus project to many sites in the CNS and the spinal cord, and vasopressin is also expressed at several other sites in the brain (see de Vries 2008), including in the olfactory bulb, where it has been implicated in social recognition (Tobin et al 2010). In addition, oxytocin is an important regulator of appetite and sexual behaviour (Baskerville & Douglas 2008).…”
Section: The Present Daymentioning
confidence: 99%