An introduction to death receptors in apoptosis

Kumar, Ravi; Herbert, Paul; Warrens, Anthony N.

doi:10.1016/j.ijsu.2005.05.002

Cited by 75 publications

(51 citation statements)

References 129 publications

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“…13). The intrinsic apoptotic pathway involves mitochondria, while the extrinsic apoptotic pathway is activated via death receptors belonging to the tumor necrosis factor alpha (TNF-a) superfamily (Almasan and Ashkenazi, 2003;Baines et al, 2003;Kumar et al, 2005). The intrinsic pathway is initiated in mitochondria in response to different stimuli Green and Reed, 1998;Kroemer, 2003), among which include high levels of cytoplasmic Ca 2+ , reactive oxygen species (ROS), the activation of pro-apoptotic Bcl-2 family proteins (Keeble and Gilmore, 2007;Kroemer et al, 2007;Le Bras et al, 2005) or UV damage (Denning et al, 2002).…”

Section: Mitochondria-mediated Apoptosismentioning

confidence: 99%

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Shoshan‐Barmatz

Pinto

Zweckstetter

et al. 2010

Molecular Aspects of Medicine

665

731

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Section: Mitochondria-mediated Apoptosismentioning

confidence: 99%

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Shoshan‐Barmatz

Pinto

Zweckstetter

et al. 2010

Molecular Aspects of Medicine

665

731

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“…Blocking TNF-α production is very effective in reducing local and systemic inflammation in patients with rheumatoid arthritis and psoriasis [92]. TNF-α promotes killing of tumour cells through apoptosis via binding with death-domains in tumour cells, stimulating NK cells and activating CD8+ cells [93]. …”

Section: Cytokine Production and Mnpsmentioning

confidence: 99%

“…There are inhibitory mechanisms that protect cells from TNF-α activity, such as circulating TNF receptors and membrane-bound “decoy” receptors [93]. …”

Section: Cytokine Production and Mnpsmentioning

confidence: 99%

Mononuclear phagocytes in head and neck squamous cell carcinoma

Kross

Heimdal

Aarstad

2009

Eur Arch Otorhinolaryngol

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The head and neck squamous cell carcinoma microenvironments contain many immune cells and their secretory products. Many of these cells belong to the mononuclear phagocyte system. The aim of this review is to study the interactions between mononuclear phagocytes and head and neck squamous cell carcinoma tissue. The role of inflammation in tumours and the cytokine interleukin-6 will be highlighted. Future therapy strategies in the treatment of head and neck cancer might be directed towards mononuclear phagocytes and their cytokine production.

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“…The intrinsic apoptotic pathway involves mitochondria, while the extrinsic apoptotic pathway is activated via death receptors belonging to the tumor necrosis factor alpha (TNF-) superfamily [129][130][131]. It is now accepted that the predominant version of apoptosis proceeds through the mitochondrial intrinsic pathway, with OMM permeabilization leading to the release of apoptotic proteins.…”

Section: The Extrinsic and Intrinsic Apoptotic Pathwaysmentioning

confidence: 99%

Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy

Shoshan‐Barmatz¹,

Golan

2012

CMC

130

127

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Found at the outer mitochondrial membrane, the voltage-dependent anion channel, VDAC, assumes a crucial position in the cell, serving as the main interface between mitochondrial and cellular metabolisms by mediating transport of ions and metabolites. VDAC thus functions as a gatekeeper, controlling cross-talk between mitochondria and the rest of the cell. Moreover, its location at the boundary between the mitochondria and the cytosol enables VDAC to interact with proteins that mediate and regulate the integration of mitochondrial functions with other cellular activities. Here, we review current knowledge related to the roles played by VDAC in the regulation of cell life and cell death, with relation to cancer. The current concepts of altered metabolism in cancer cells are presented with specific emphasis on mitochondrial, more specifically VDAC1-bound hexokinase (HK), facilitating and promoting the high glycolytic tumor phenotype. In this respect, the up-regulation of HK expression in tumor cells and its binding to VDAC provide both a metabolic benefit and apoptosis-suppressive capacity that offers the cell a growth advantage and increases its resistance to chemotherapy. VDAC has also been recognized as a key protein in mitochondria-mediated apoptosis since it is the proposed target for the pro- and antiapoptotic Bcl-2-family of proteins, as well as due to its function in the release of apoptotic proteins located in the inter-membranal space. These and other functions point to VDAC1 as being a rational target for the development of a new generation of therapeutics.

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An introduction to death receptors in apoptosis

Cited by 75 publications

References 129 publications

VDAC, a multi-functional mitochondrial protein regulating cell life and death

VDAC, a multi-functional mitochondrial protein regulating cell life and death

Mononuclear phagocytes in head and neck squamous cell carcinoma

Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy

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