An array of samples from the eastern Upper Basin Member of the Plateau Rhyolite (EUBM) in the Yellowstone Plateau, Wyoming, were collected and analyzed to evaluate styles of deposition, geochemical variation, and plausible sources for low d 18 O rhyolites. Similar depositional styles and geochemistry suggest that the Tuff of Sulphur Creek and Tuff of Uncle Tom's Trail were both deposited from pyroclastic density currents and are most likely part of the same unit. The middle unit of the EUBM, the Canyon flow, may be composed of multiple flows based on a wide range of Pb isotopic ratios (e.g., 206 Pb/ 204 Pb ranges from 17.54 to 17.86). The youngest EUBM, the Dunraven Road flow, appears to be a ring fracture dome and contains isotopic ratios and sparse phenocrysts that are similar to extra-caldera rhyolites of the younger Roaring Mountain Member. Petrologic textures, more radiogenic 87 Sr/ 86 Sr in plagioclase phenocrysts (0.7134-0.7185) than groundmass and whole-rock ratios (0.7099-0.7161), and d 18 O depletions on the order of 5% found in the Tuff of Sulphur Creek and Canyon flow indicate at least a twostage petrogenesis involving an initial source rock formed by assimilation and fractional crystallization processes, which cooled and was hydrothermally altered. The source rock was then lowered to melting depth by caldera collapse and remelted and erupted. The presence of a low d 18 O extra-caldera rhyolite indicates that country rock may have been hydrothermally altered at depth and then assimilated to form the Dunraven Road flow.