An introduction to methodology, psychophysiological significance and clinical applications

Licht, R.; Hömberg, V.

doi:10.1007/978-94-009-2059-0_11

Cited by 3 publications

(1 citation statement)

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“…[12][13][14] The ERPs give an idea regarding the timeline of information processing involved in expectancy, attention, cognition search, decision-making, and memorization. 15 ERP is the extrinsic recording of the internal electrical activity of the underlying brain structure emerging from a stimulus bound activity. This is documented by using an unconventional model in which the individual is vigilant and consciously discriminates an auditory stimulus from a cluster of other auditory stimuli.…”

Section: The Event-related Potentialmentioning

confidence: 99%

Study of Neurocognitive Function in Type 2 Diabetes Mellitus Patients Using P300 Event-Related Potential

Swaminathan

Ramanathan²,

Arulmurugan

et al. 2020

Annals of Neurosciences

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Background: Diabetes mellitus is the most prevailing metabolic disease. It causes structural and functional alterations in several organs, including the central nervous system. Altered glucose metabolism, atherosclerosis, and inflammation of blood vessels are seen in diabetes. This may lead to neuronal degeneration and decline in cognition. Event-related potential P300 can detect cognitive decline before the emergence of obvious neurological manifestations. Objective: The aim of this study is to assess and compare the P300 latencies in subjects with type 2 diabetes mellitus and in nondiabetic subjects and to determine the influence of type 2 diabetes mellitus on cognitive functions. Materials and Methods: In this study our sample size was 248 subjects, with type 2 diabetes mellitus patients ( n = 124) and healthy controls ( n = 124) between the age group of 31 and 60 years. This cross-sectional comparative study was conducted at SRM Medical College Hospital and Research Centre. The subjects were evaluated by a structured interview and they were assessed with a general health questionnaire to rule out any subpsychiatric illness. Fasting and postprandial blood glucose, HbA1c level, lipid profile, and creatinine were estimated. P300 amplitude and peak latencies were recorded using the standard auditory oddball paradigm. Results: The latencies of P300 were significantly increased and the amplitude of P300 was significantly reduced in the diabetic group when compared to the control group ( P < .001). P300 latency has a positive correlation with the HbA1c levels ( r = 0.136) and the duration of diabetes ( r = 0.231). Conclusion: Prolongation of P300 latencies and the decreased amplitude in diabetic subjects may suggest the existence of a cognitive decline in individuals with type 2 diabetes compared to healthy individuals.

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Section: The Event-related Potentialmentioning

confidence: 99%