An inverse relationship between plasma glutathione concentration and fasting glycemia in patients with coronary artery disease and concomitant type 2 diabetes: A pilot study

Karolczak, Kamil; Kubalczyk, Paweł; Głowacki, Rafał; Pietruszyński, Robert; Watała, Cezary

doi:10.17219/acem/65441

Cited by 11 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides increased glucose level in the plasma, the M group demonstrated upregulated fructose and mannose metabolism, which was in line with a previous diabetes study [ 27 ]. Glutathione metabolism was upregulated in the M group and mainly contributed to by increased glutathione; however, glutathione is an antioxidant and has been reported to be inversely correlated with fasting glycemia in patients with type 2 diabetes [ 28 ], which was contrary to the result in this study and deserved further investigation. The relationship between steroid metabolism and diabetes has been established.…”

Section: Discussioncontrasting

confidence: 99%

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

Wang

Chen

Wang

et al. 2022

Foods

View full text Add to dashboard Cite

Rosa roxburghii fruit is an underutilized functional food abundant in polyphenols. Polyphenols have been proved to have antidiabetic effects. This study investigates the effects of Rosa roxburghii fruit polyphenols extract (RPE) on plasma metabolites and gut microbiota composition in streptozotocin (STZ)- and high-fat diet- induced type 2 diabetes using metabolomics and 16S rRNA gene sequencing. The induced diabetic mice were fed with 400 mg/kg body weight RPE for 8 weeks. RPE demonstrated hypoglycemic, hypolipidemic, and anti-inflammatory effects. Colonic oxidative stress biomarkers were also lowered by RPE. Besides, RPE decreased plasma ceramides and tyrosine levels and increased carnitine and phosphatidylinositols levels, indicating improved insulin resistance, lipid metabolism, and immune response. Furthermore, RPE decreased abundances of Lachnospiraceae and Rikenellaceae and increased abundances of Erysipelotrichaceae and Faecalibaculum. Metabolic function prediction of the gut microbiota by PICRUSt demonstrated that RPE downregulated the phosphotransferase system. Taken together, these findings demonstrated that RPE has the potential to prevent type 2 diabetes by regulating the plasma metabolites and gut microbes.

show abstract

Section: Discussioncontrasting

confidence: 99%

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

Wang

Chen

Wang

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

“…В другом исследовании было выявлено снижение РС Глн в плазме крови при СД 2-го типа [5]. Также было отмечено, что СД 2-го типа является фактором, усиливающим отрицательную связь между уровнем глюкозы и уровнем оГлн в плазме крови у пациентов с ишемической болезнью сердца (ИБС) [6]. Возможно, что в этом определенную роль играет повышение активности γ-глутамилцистеинтрансферазыфермента, участвующего в синтезе Глн, так как выявлена тесная корреляция активности γ-глутамилцистеинтрансферазы с уровнем глюкозы [4].…”

unclassified

“…Обсуждение. Глн является основным тиолосодержащим внутриклеточным антиоксидантом и одним из факторов регуляции метаболизма глюкозы, особенно у лиц с сердечно-сосудистыми заболеваниями [6]. Так, влиянием Глн на уровень глюкозы в крови было обусловлено снижение прогрессирования глюкозо-зависимых изменений сосудистой стенки, обусловленных артериальной гипертензией [11].…”

unclassified

“…Было показано, что у больных с ИБС уровень глюкозы в плазме крови обратно коррелирует с уровнем оГлн. У больных СД эта закономерность отмечалась как при ИБС, так и без нее [6].…”

unclassified

“…В ее основе лежит хронический ОС и связанная с ним митохондриальная дисфункция. Гипергликемия индуцирует ОС путем снижения уровней витаминов E и C, мочевой кислоты [6] с последующим истощением общего антиоксидантного статуса [4]. Уровень глюкозы в этом случае является модулирующим фактором, который снижает порог патологического сигналинга активных форм кислорода и азота [17].…”

unclassified

See 2 more Smart Citations

Type 2 diabetes mellitus in patients with acute ischemiс stroke is associated with a decrease in plasma glutathione levels

Maksimova

Иванов

Nikiforova

et al. 2020

РНЖ

View full text Add to dashboard Cite

Ischemic stroke (IS) and type 2 diabetes mellitus are factors that aﬀect the homeostasis of low-molecularweight aminothiols (cysteine, homocysteine, glutathione etc.). It has already been shown that IS in the acute period led to a decrease a level of reduced forms of aminothiols, but it is not clear whether type 2 diabetes mellitus has a noticeable eﬀect there. Objective: to reveal the features of homeostasis of aminothiols in patients with type 2 diabetes mellitus in acute IS. Material and methods. The study involved 76 patients with primary middle cerebral artery IS in the first 10–24 hours after development of neurological symptoms. Group 1 included 15 patients with IS and type 2 diabetes mellitus, group 2 — 61 patients with IS and stress hyperglycemia. Their total plasma levels of cysteine, homocysteine, and glutathione, their reduced forms, and redox status were determined at admission (in the first 24 hours after IS). Results. There was a decrease in the level of total glutathione level (1.27 vs. 1.65 μM, p = 0.021), as well as its reduced form (0.03 vs. 0.04 μM, p = 0.007) in patients with IS and type 2 diabetes mellitus. Patients with type 2 diabetes mellitus who had a low redox status of homocysteine (0.65–1.2%) and glutathione (0.7–2.0%) were also characterized by a decrease in total glutathione level (p = 0.02; p = 0.03). Conclusion. Thus, type 2 diabetes mellitus is associated with a decrease in the level of total glutathione in acute IS. Probably, type 2 diabetes mellitus is characterized by a particular relationship between the metabolism of homocysteine, glutathione and glucose. Therefore, the search for homocysteine-dependent approaches to correct glutathione metabolism in type 2 diabetes mellitus may be of interest as an adjuvant therapy for IS.

show abstract

Overview and recent advances in electrochemical sensing of glutathione – A review

Hanko

Švorc

Planková

et al. 2019

Analytica Chimica Acta

110

View full text Add to dashboard Cite

An inverse relationship between plasma glutathione concentration and fasting glycemia in patients with coronary artery disease and concomitant type 2 diabetes: A pilot study

Abstract: The study suggests that GSH may be an important factor contributing to glucose metabolism in CAD patients. Hence, it may be considered a significant therapeutic target in strategies aimed at improving glycemic control in CAD-affected subjects.

Cited by 11 publications

References 24 publications

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

The Effect of Polyphenol Extract from Rosa Roxburghii Fruit on Plasma Metabolome and Gut Microbiota in Type 2 Diabetic Mice

Type 2 diabetes mellitus in patients with acute ischemiс stroke is associated with a decrease in plasma glutathione levels

Overview and recent advances in electrochemical sensing of glutathione – A review

Contact Info

Product

Resources

About