An investigation into the clinical effects of fast neutrons

Catterall, Mary; Rogers, Charles C.; Thomlinson, R. H.; Field, S. B.

doi:10.1259/0007-1285-44-524-603

Cited by 75 publications

(12 citation statements)

References 13 publications

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“…Examples include a modified CTCAE scale which subdivides grade 2 toxicities into three subcategories based on the presence of erythema, dry desquamation, or wet desquamation;39,40 a modified RTOG scale which subdivides grade 2 toxicities into two categories;41,42 the Radiation-Induced Skin Reaction Assessment Scale (RISRAS) which individually scores the extent and severity of erythema, dry desquamation, moist desquamation, and necrosis;43,44 and the 10-point Catterall skin scoring profile 31,45…”

Section: Assessment and Scoringmentioning

confidence: 99%

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Kole¹,

Kole²,

Moran³

2017

BCTT

102

106

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Nearly all women who receive radiotherapy (RT) for breast cancer experience some degree of radiation dermatitis. However, evidence describing the appropriate management of radiation dermatitis is often lacking or contradictory. Here, we summarize the available literature regarding radiation dermatitis causes, the presentation and timing of symptoms, methods for dermatitis assessment and prevention, and review evidence-based management strategies.

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Section: Assessment and Scoringmentioning

confidence: 99%

Acute radiation dermatitis in breast cancer patients: challenges and solutions

Kole¹,

Kole²,

Moran³

2017

BCTT

102

106

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“…Future studies may consider scales such as the Radiation-Induced Skin Reaction Assessment Scale which allow clinicians to separately grade erythema, dry desquamation, moist desquamation, and necrosis based on presence and surface area [20]. Other alternatives include the National Cancer Institute Common Toxicity Criteria for Adverse Events and the Catterall skin scoring profile, a ten-point scale that ranges from no visible reaction to ulceration [21-22]. Additionally, spectroscopy and software programs have been used to reliably score each patient, though this method is more time and resource intensive [23-24].…”

Section: Discussionmentioning

confidence: 99%

Phase III Randomized Pair Comparison of a Barrier Film vs. Standard Skin Care in Preventing Radiation Dermatitis in Post-lumpectomy Patients with Breast Cancer Receiving Adjuvant Radiation Therapy

Lam¹,

Yu²,

Vanwynsberghe³

et al. 2019

Cureus

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Introduction Patients undergoing adjuvant radiotherapy to the breast often experience radiation dermatitis ranging from mild erythema to moist desquamation. In post-lumpectomy patients, the axilla and inframammary fold are at an increased risk for friction dermatitis. Dermatitis can impact patients’ quality-of-life and may require treatment break/cessation. Our objectives are to assess the efficacy of 3M Cavilon Barrier Film (BF) in preventing and/or delaying the onset of grade-two dermatitis and reducing patient-reported sensation scores. Methods A total of 55 patients were randomized to receive BF on the medial or lateral breast. BF was applied twice weekly during treatment. Skin toxicity was evaluated weekly by a blinded clinical investigator using the Skin Toxicity Assessment Tool (STAT) and the modified Radiation Therapy Oncology Group Visual Assessment Score (RTOG VAS). On day one, baseline photographs were taken; seven-to-ten days post-treatment, patients returned for photographs, the STAT/RTOG VAS, and patient-opinion questions in the form of the global questionnaire. Results The paired analysis found BF did not significantly reduce dermatitis either during or post-treatment. However, the unpaired analysis found significantly reduced RTOG VAS on the lateral compartment during treatment (BF:0.91 vs. Control:1.21, p = 0.0408). This difference resolved post-treatment. Additionally, BF was able to reduce pruritus ( p = 0.047) on the medial components and burning sensations on the lateral components ( p = 0.035). There was no significant difference between the time-to-onset or proportion of patients who developed grade-two dermatitis. Conclusion In an unpaired analysis, BF significantly reduced dermatitis on the lateral compartment during treatment. Additionally, BF significantly reduced pruritus and burning sensations. A larger study using a more reliable scoring method is required to clarify the effect of BF on radiation-associated skin toxicity.

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“…In their clinical investigations of neutron irradiations, Catterall, Rogers, Thomlinson, and Field (1971) concluded that 1440 rad of fast neutrons, or 4200 rad of orthovoltage X-rays, delivered in 12 fractions (three per week) over 25 days, caused a skin reaction within acceptable limits, and led to early response of the irradiated tumors. Since these irradiations imply that the survival of kidney or leukemia cells so irradiated lies between 25 and 40% per dose fraction, we take it to be a clinical constraint that the dose delivered in a single fraction to a tumor is one for which there would be, say, 30% survival of aerobically irradiated kidney cells within the tumor volume, and that if this dose is repeated according to this (Hammersmith Hospital) schedule, there will be an acceptable reaction of normal tissue in the tumor region and, from the Hammersmith experience, a satisfactory early response of Table 1, as an indication of the potential range of the results of charged particle irradiations.…”

Section: Heavy Ion Therapy : Preclinical Radiobiological Calculationsmentioning

confidence: 99%