Heavy particles in therapy: an application of track theory

Katz, Robert; Sharma, Sanjeev

doi:10.1088/0031-9155/19/4/001

Cited by 34 publications

(12 citation statements)

References 18 publications

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“…Dynamics of intestinal stem cell compartment, its niche and the progeny in relation to radiation quality dependent oxidative stress remains an important area for investigation in the future to delineate the tissue specific delayed effects of high-LET radiation. Available literature predict that direct traversal by a primary heavy ion particle track due to its high-LET characteristics would most likely result in apoptosis or reproductive death of the stem cell and will not be able to pass on any changes to the progeny [69], [70]. This raises the likelihood that an element of either non-targeted ‘bystander’ effect or targeted secondary delta ray effects is playing an important role in the radiation quality dependent persistent oxidative stress in IEC [24], [55], [71], [72] ( Figure 8 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

et al. 2012

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Ionizing radiation-induced oxidative stress is attributed to generation of reactive oxygen species (ROS) due to radiolysis of water molecules and is short lived. Persistent oxidative stress has also been observed after radiation exposure and is implicated in the late effects of radiation. The goal of this study was to determine if long-term oxidative stress in freshly isolated mouse intestinal epithelial cells (IEC) is dependent on radiation quality at a dose relevant to fractionated radiotherapy. Mice (C57BL/6J; 6 to 8 weeks; female) were irradiated with 2 Gy of γ-rays, a low-linear energy transfer (LET) radiation, and intestinal tissues and IEC were collected 1 year after radiation exposure. Intracellular ROS, mitochondrial function, and antioxidant activity in IEC were studied by flow cytometry and biochemical assays. Oxidative DNA damage, cell death, and mitogenic activity in IEC were assessed by immunohistochemistry. Effects of γ radiation were compared to 56Fe radiation (iso-toxic dose: 1.6 Gy; energy: 1000 MeV/nucleon; LET: 148 keV/µm), we used as representative of high-LET radiation, since it's one of the important sources of high Z and high energy (HZE) radiation in cosmic rays. Radiation quality affected the level of persistent oxidative stress with higher elevation of intracellular ROS and mitochondrial superoxide in high-LET 56Fe radiation compared to unirradiated controls and γ radiation. NADPH oxidase activity, mitochondrial membrane damage, and loss of mitochondrial membrane potential were greater in 56Fe-irradiated mice. Compared to γ radiation oxidative DNA damage was higher, cell death ratio was unchanged, and mitotic activity was increased after 56Fe radiation. Taken together our results indicate that long-term functional dysregulation of mitochondria and increased NADPH oxidase activity are major contributing factors towards heavy ion radiation-induced persistent oxidative stress in IEC with potential for neoplastic transformation.

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Section: Discussionmentioning

confidence: 99%

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

et al. 2012

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“…307 A propeller to produce a depth dose for constant cell killing was also described by Katz and Sharma. 308 Using a propeller to modulate the range of the beam from a synchrotron requires several refinements. First, the extracted beam from the accelerator must be of long duration and maintained at a constant level, i.e., flat-top extraction.…”

Section: Iib2 Range-modulating Propellersmentioning

confidence: 99%

Instrumentation for treatment of cancer using proton and light-ion beams

Chu

Ludewigt

Renner

1993

Review of Scientific Instruments

287

186

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Clinical trials using accelerated heavy charged-particle beams for treating cancer and other diseases have been performed for nearly four decades. Recently there have been worldwide efforts to construct hospital-based medically dedicated proton or light-ion accelerator facilities. To make such accelerated heavy charged-particle beams clinically useful, specialized instruments must be developed to modify the physical characteristics of the particle beams in order to optimize their biological and clinical effects. This article reviews the beam modifying devices and associated dosimetric equipment developed specifically for controlling and monitoring the clinical beams.

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“…• The Katz track structure model [8] - [9] assumes two different modes of cell killing: a γ-kill mode, in which sub-lethal damages derive from δ-rays, and an ion-kill mode, according to which a cell may be inactivated by the passage of a primary ion through its nucleus or by a long-range δ-ray deriving from a primary ion passing outside its nucleus.…”

Section: Cell Survival Modelsmentioning

confidence: 99%

Models of biological effects of radiation in the Geant4 Toolkit

Chauvie

Francis

Guatelli

et al. 2006

2006 IEEE Nuclear Science Symposium Conference Record

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A project, named Geant4-DNA, is in progress to extend the Geant4 simulation toolkit to model the effects of radiation with biological systems at cellular and DNA level. The first component implemented in the first development cycle of the project describes the fractional survival of a population of cells irradiated with photons or charged particles. The software system developed provides the user the option to choose among a small set of alternative models for the calculation of mammalian cell survival after irradiation. The flexible design adopted makes the system open to further extension to implement other cell survival models available in literature. The preliminary design of a prototype of the cell survival models implemented and preliminary results in some selected cell lines are described. The preliminary design of a prototype of the cell survival models implemented and preliminary results in some selected cell lines are described.

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Heavy particles in therapy: an application of track theory

Cited by 34 publications

References 18 publications

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

Exposure to Heavy Ion Radiation Induces Persistent Oxidative Stress in Mouse Intestine

Instrumentation for treatment of cancer using proton and light-ion beams

Models of biological effects of radiation in the Geant4 Toolkit

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