An investigation into the polylactic acid texturization through thermomechanical processing and the improved d33 piezoelectric outcome of the fabricated scaffolds

Farahani, Amirhossein; Zarei-Hanzaki, A.; Abedi, H.R.; Haririan, Ismaeil; Akrami, Mohammad; Aalipour, Zeynab; Tayebi, Lobat

doi:10.1016/j.jmrt.2021.11.048

Cited by 19 publications

(8 citation statements)

References 47 publications

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“…As reported earlier, the same mechanical stimulus in the implantation area with these piezoelectric fiber‐hydrogel composite scaffolds generates a higher value of the electrical voltage, which can improve bone growth 2,13,66 . In a study by Farahani et al, the improvement of the piezoelectric value of polylactic acid as a scaffold was observed with a 0.21 fC N −1 value 67 . According to the literature, the conductivity values of cancellous and cortical bones are 0.16–0.2 and 0.058–0.063 S m −1 , respectively, implying the electrical conductive properties of bone 68 .…”

Section: Discussionsupporting

confidence: 52%

“…2,13,66 In a study by Farahani et al, the improvement of the piezoelectric value of polylactic acid as a scaffold was observed with a 0.21 fC N À1 value. 67 According to the literature, the conductivity values of cancellous and cortical bones are 0.16-0.2 and 0.058-0.063 S m À1 , respectively, implying the electrical conductive properties of bone. 68 The electrical conductivity of ADA/gelatin/PPy-g-gelatin (8% wt/vol, 30:35:35% vol/vol) hydrogel was measured to be 0.77 S m À1 , as reported earlier in previous work.…”

Section: Discussionmentioning

confidence: 99%

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Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering

Samghabadi

Karkhaneh

Katbab

2023

Polymers for Advanced Techs

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In recent years, materials with piezoelectric and electroconductive behavior have been thought interesting and important to be used for bone scaffolds due to their potential in mimicking the bone tissues. In the present work, attempts have been made to prepare three-dimensional laminated scaffolds by means of embedding the piezoelectric polyvinylidene fluoride (PVDF)/polylactic acid (PLA) electrospun nanofibrous mats into the electroconductive porous oxidized alginate (ADA)/gelatin/polypyrrole-graft-gelatin (PPy-g-gelatin) hydrogel precursor structure to obtain a biphasic layered structure (a fiber-hydrogel scaffold). The morphology, tensile strength, β-phase contents, and crystallinity of the fibers are evaluated. The compressive modulus of the electrospun fiber-hydrogel composites (32.72 MPa) shows to be much higher than the neat hydrogel (0.01 MPa). The prepared composites present high electrical conductivity (1.8 S m À1 ) and piezoelectric coefficient (1.61 fC N À1 ). By incorporating the fibers into the hydrogel structure, the cross-link density of the composite is increased. The swelling ratio, porosity, and rate of biodegradation of the fabricated composites are also investigated. Moreover, good biocompatibility of human osteosarcoma cells attached to the PVDF/PLA nanofibers-ADA/gelatin/PPyg-gelatin hydrogel scaffold is evidenced by alkaline phosphatase assay, alizarin red and hematoxylin and eosin staining, and osteogenic gene expression evaluation. The prepared osteon-mimetic samples with the synergized features of piezoelectricity and electrical conductivity can potentially be used as three-dimensional scaffolds for bone tissue engineering.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering

Samghabadi

Karkhaneh

Katbab

2023

Polymers for Advanced Techs

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“…47−49 One may notice that the HABE-modified PLA membranes presented a damped T m at 148.3 °C, which was principally associated with the induced Efield repulsion of polarized HABE to amorphous PLA that disengaged the adjacent PLA chains and new α' phase formation. 50,51 The melting enthalpy (ΔH) decreased from 30.4 (pure PLA) to 23.2 J/g (PLA/HABE30), further verifying that the proportion of the amorphous phase in the HABEmodified PLA molecular chain was increased. 48,52 Third, the highest content of HABE resulted in the lowest crystallinity (12.0%) of PLA/HABE30, which indicated that HABE induced the formation of the electrospun phase and that charged bioelectret poling amorphous PLA chains increased the free volume, which enhanced the polarizability of electrospun HABE-PLA (Figure 3f).…”

Section: ■ Results and Discussionmentioning

confidence: 76%

“…First, the T g of PLA was reduced to 56.7 °C for the membrane containing 30 wt % HABE. This was mainly derived from the formation of supernumerary free volumes with polarized PLA chains, which could cause a reduction in T g . − One may notice that the HABE-modified PLA membranes presented a damped T m at 148.3 °C, which was principally associated with the induced E-field repulsion of polarized HABE to amorphous PLA that disengaged the adjacent PLA chains and new α’ phase formation. , The melting enthalpy (Δ H ) decreased from 30.4 (pure PLA) to 23.2 J/g (PLA/HABE30), further verifying that the proportion of the amorphous phase in the HABE-modified PLA molecular chain was increased. , Third, the highest content of HABE resulted in the lowest crystallinity (12.0%) of PLA/HABE30, which indicated that HABE induced the formation of the electrospun phase and that charged bioelectret poling amorphous PLA chains increased the free volume, which enhanced the polarizability of electrospun HABE-PLA (Figure f) . Due to the increase in the electrospun amorphous phase, there may be many local states in the energy gap of electret dielectric materials with high distributed trap depth values. , The electrospun phase formation is connected to the strong electroactive HBAE-modified PLA membrane, which could represent a high dielectric constant and electrostatic potential.…”

Section: Results and Discussionmentioning

confidence: 99%

Bioelectrets in Electrospun Bimodal Poly(lactic acid) Fibers: Realization of Multiple Mechanisms for Efficient and Long-Term Filtration of Fine PMs

Tang

Jiang

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Despite the great potential in fabrication of biodegradable and eco-friendly air filters by electrospinning poly(lactic acid) (PLA) membranes, the filtering performance is frequently dwarfed by inadequate physical sieving or electrostatic adsorption mechanisms to capture airborne particulate matters (PMs). Here, using the parallel spinning approach, the unique micro/nanoscale architecture was established by conjugation of neighboring PLA nanofibers, creating bimodal fibers in electrospun PLA membranes for the enhanced slip effect to significantly reduce the air resistance. Moreover, the bone-like nanocrystalline hydroxyapatite bioelectret (HABE) was exploited to enhance the dielectric and polarization properties of electrospun PLA, accompanied by the controlled generation of junctions induced by the microaggregation of HABE (10–30 wt %). The incorporated HABE was supposed to orderly align in the applied E-field and largely promote the charging capability and surface potential, gradually increasing to 7.2 kV from the lowest level of 2.5 kV for pure PLA. This was mainly attributed to HABE-induced orientation of PLA backbone chains and CO dipoles, as well as the interfacial charges trapped at the interphases of HABE–PLA and crystalline region–amorphous PLA. Given the multiple capturing mechanisms, the micro/nanostructured PLA/HABE membranes were characterized by excellent and sustainable filtering performance, e.g., the filtration efficiency of PM0.3 was promoted from 59.38% for pure PLA to 94.38% after addition of 30 wt % HABE at a moderate airflow capacity of 32 L/min and from 30.78 to 83.75% at the highest level of 85 L/min. It is of interest that the pressure drop was significantly decreased, mainly arising from the slip effect between the ultrafine nanofibers and conjugated microfibers. The proposed combination of the nanostructured electret and the multistructuring strategy offers the function integration of efficient filtration and low resistance that are highly useful to pursue fully biodegradable filters.

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“…[142,143] The experiments revealed that the PLLA has piezoelectricity parallel to the z-axis with a d 14 coefficient of 7-12 pC N −1 . [144,145] The stretching treatment in PLA and PLLA can orient the chains and enhance piezoelectricity. Smith et al [146] measured the piezoelectric coefficient in the highly oriented nanowires grown in the anodized aluminum oxide (AAO) confined environment.…”

Section: Synthetic Biodegradable Piezoelectric Polymersmentioning

confidence: 99%

Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

Mohsin

Bathaei

Istif

et al. 2023

Adv Healthcare Materials

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Recent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, and biocompatible functional materials. As a fundamental electromechanical coupling material in numerous applications, novel piezoelectric materials with a feature of degradability and desired electrical and mechanical properties are being developed for future wearable and implantable bioelectronics. These bioelectronics can be easily integrated with biological systems for applications, including sensing physiological signals, diagnosing medical problems, opening the blood‐brain barrier, and stimulating healing or tissue growth. Therefore, the generation of piezoelectricity from natural and synthetic bioresorbable polymers has drawn great attention in the research field. Herein, the significant and recent advancements in biodegradable piezoelectric materials, including natural and synthetic polymers, their principles, advanced applications, and challenges for medical uses, are reviewed thoroughly. The degradation methods of these piezoelectric materials through in vitro and in vivo studies are also investigated. These improvements in biodegradable piezoelectric materials and microsystems could enable new applications in the biomedical field. In the end, potential research opportunities regarding the practical applications are pointed out that might be significant for new materials research.

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An investigation into the polylactic acid texturization through thermomechanical processing and the improved d33 piezoelectric outcome of the fabricated scaffolds

Cited by 19 publications

References 47 publications

Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering

Synthesis and characterization of biphasic layered structure composite with simultaneous electroconductive and piezoelectric behavior as a scaffold for bone tissue engineering

Bioelectrets in Electrospun Bimodal Poly(lactic acid) Fibers: Realization of Multiple Mechanisms for Efficient and Long-Term Filtration of Fine PMs

Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

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