An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion

Khoee, Sepideh; Yaghoobian, Morteza

doi:10.1016/j.ejmech.2008.09.045

Cited by 109 publications

(53 citation statements)

References 27 publications

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“…The morphological characteristics of the nanoparticles were evaluated using a scanning electron microscope (Philips XL30 ESEM, Eindhoven, Netherlands). 28,29 Nanoparticle yield (%)…”

Section: Morphology Of the Nanoparticlesmentioning

confidence: 99%

Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

2012

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Linamarin-loaded poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by using a double emulsion solvent evaporation method using polyvinyl alcohol as a surfactant. A two-factor full factorial design, Box-Behnken design and surface response methodology, were employed to improve the nanoparticle yield, particle size, and drug encapsulation efficiency OPTIMIZING ENCAPSULATION OF LINAMARIN PLGA NANOPARTICLESby determining the optimum levels of the process parameters, namely the polymer concentration, surfactant concentration, and homogenization speed. Both linear and quadratic empirical models were developed to express each response parameter as a function of the studied factors. A total of 12 and 17 experimental runs were necessary to obtain adequate empirical models ( p < 0.05) for both factorial and Box-Behnken designs, respectively. The final optimum values for the polymer concentration, surfactant concentration, and homogenization speed were determined at 9.8 mg/mL, 50 mg/mL, and 23,000 rpm, respectively. Formulations obtained at this optimum preparing condition resulted on average 96% yield, 61.2% drug encapsulation efficiency, and 144.6 nm particle size. However, all prepared nanoparticles showed some kind of controlled drug release; most likely the final optimized nanoparticles exhibited the most biphasic controlled drug release profile with a minimal burst release and overall drug release of <30% in 120 h of incubation. C

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“…The morphological characteristics of the nanoparticles were evaluated using a scanning electron microscope (Philips XL30 ESEM, Eindhoven, Netherlands). 28,29 Nanoparticle yield (%)…”

Section: Morphology Of the Nanoparticlesmentioning

confidence: 99%

Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

2012

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“…However, the hydrophilic head of DLP attaches to the particles surface leaving the hydrophobic tail away from the particles surface (20). This preferential adsorption of DLP onto the particles surface restricts the interconnection of particles and prevents agglomeration, thus reducing the particle size (20)(21)(22). The polydispersity index of all the formulations was in the range of 0.2 to 0.8, revealing its monodispersity nature for all the synthesized nanoparticles (Table II).…”

Section: Physicochemical Characterization Of Nanoparticlesmentioning

confidence: 90%

“…Hence, the higher loading efficiency observed in D1 and D2 formulation is primarily attributed to the involvement of DLP. The same parameters that decrease the mean size of the particles could also increase the encapsulation efficiency (20,22). The chain length and size of the hydrophilic head group of non-ionic surfactants affect the entrapment efficiency as is evident with DLP which has a long chain length (C12) and correspondingly higher entrapment efficiency (22,28).…”

Section: Drug Encapsulation Efficiencymentioning

confidence: 91%

“…This decrease in particle size upon the addition of DLP was attributed to its non-ionic surfactant nature (20). Typically, non-ionic surfactants consist of polyoxyethylene moieties with a hydrophilic head and a hydrophobic tail (20)(21)(22). During ultrasonication, interparticulate collisions occur which causes the agglomeration of particles.…”

Section: Physicochemical Characterization Of Nanoparticlesmentioning

confidence: 99%

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Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

et al. 2015

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Abstract. The most successful treatment strategy for arthritis is intra-articular injections that are costly and have reduced patient compliance. The purpose of the current study was to develop an inflammationsensitive system for topical drug administration. Multi-macromolecular alginate-hyaluronic acid-chitosan (A-H-C) polyelectrolyte complex nanoparticles, loaded with indomethacin were developed employing pre-gel and post-gel techniques in the presence of dodecyl-L-pyroglutamate (DLP). In addition to in vitro studies, in silico simulations were performed to affirm and associate the molecular interactions inherent to the formulation of core all-natural multi-component biopolymeric architectures composed of an anionic (alginate), a cationic (chitosan), and an amphi-ionic polyelectrolytic (hyaluronic acid) macromolecule. The results demonstrated that DLP significantly influenced the size of the synthesized nanoparticles. Drug-content analysis revealed higher encapsulation efficiency (77.3%) in the presence of DLP, irrespective of the techniques used. Moreover, in vitro drug release studies showed that indomethacin release from the nanosystem was significantly improved (98%) in Fenton's reagent. Drug permeation across a cellulose membrane using a Franz diffusion cell system showed an initial surge flux (0.125 mg/cm −2 /h), followed by sustained release of indomethacin for the post-gel nanoparticles revealing its effective skin permeation efficiency. In conclusion, the study presents novel nanoparticles which could effectively encapsulate and deliver hydrophobic drugs to the target site, particularly for arthritis.

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“…This reservoir can be either hydrophilic or hydrophobic according to the preparation method and the raw materials used. 2 The role of selenium (Se) as an antioxidant and anticancer agent is very well documented in the literature. 3 In addition, it has been proved that ideal concentration of selenium can restore the sensitivity for chemotherapeutic agent of cytostatic-resistant malignant cells.…”

Section: Introductionmentioning

confidence: 99%

Selol-loaded magnetic nanocapsules: A new approach for hyperthermia cancer therapy

Falqueiro

Primo

Morais

et al. 2011

Journal of Applied Physics

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Polylactic-co-glycolic nanocapsules, loaded with nanosized magnetic particles and Selol (a selenium-based anticancer drug), were successfully prepared by the precipitation method. Maghemite (γ-Fe2O3) nanoparticles were incorporated into the nanocapsules using a highly stable ionic magnetic fluid sample. The obtained nanocapsules presented no agglomeration, negative surface charge while revealing a narrow monomodal size distribution. All the nanocapsule formulations exhibited a good physical stability at 4 °C during 3 month storage period. The in vitro antitumoral activity of Selol-magnetic nanocapsules was assessed using a murine melanoma cell line. The influence of nanocapsules on cell viability was investigated by spectrophotometric assay. The results demonstrated that Selol-loaded magnetic nanocapsules (at 100 μg/ml/5 × 109 particle/ml) showed antitumoral activity of 50% on melanoma cells (absence of magnetic field). These results clearly indicate that the loaded nanocapsules represent a novel and promising magnetic drug delivery system suitable for cancer treatment via the active drug and magnetohyperthermia.

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An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion

Cited by 109 publications

References 27 publications

Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

Optimizing the Process Parameters for Encapsulation of Linamarin into PLGA Nanoparticles Using Double Emulsion Solvent Evaporation Technique

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

Selol-loaded magnetic nanocapsules: A new approach for hyperthermia cancer therapy

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