Selol-loaded magnetic nanocapsules: A new approach for hyperthermia cancer therapy

Abstract

Polylactic-co-glycolic nanocapsules, loaded with nanosized magnetic particles and Selol (a selenium-based anticancer drug), were successfully prepared by the precipitation method. Maghemite (γ-Fe2O3) nanoparticles were incorporated into the nanocapsules using a highly stable ionic magnetic fluid sample. The obtained nanocapsules presented no agglomeration, negative surface charge while revealing a narrow monomodal size distribution. All the nanocapsule formulations exhibited a good physical stability at 4 °C during 3 month storage period. The in vitro antitumoral activity of Selol-magnetic nanocapsules was assessed using a murine melanoma cell line. The influence of nanocapsules on cell viability was investigated by spectrophotometric assay. The results demonstrated that Selol-loaded magnetic nanocapsules (at 100 μg/ml/5 × 109 particle/ml) showed antitumoral activity of 50% on melanoma cells (absence of magnetic field). These results clearly indicate that the loaded nanocapsules represent a novel and promising magnetic drug delivery system suitable for cancer treatment via the active drug and magnetohyperthermia.

Co-nanoencapsulation of magnetic nanoparticles and selol for breast tumor treatment: in vitro evaluation of cytotoxicity and magnetohyperthermia efficacy

“…17 The polymeric nanocapsules were prepared according to a modified precipitation method previously described. 16 Briefly, PLGA 50:50 polymer (Sigma-Aldrich Co, St Louis, MO), selol 5%, and phosphatidylcholine (Gerbras, Anápolis, Brazil) were dissolved in acetone (JT Baker, Phillipsburg, NJ) at 40°C. This organic phase was added into an aqueous phase containing the poloxamer 188 (Sigma-Aldrich Co) and the ionic magnetic fluid sample (added into the preparation of magnetic nanocapsules).…”

“…Moreover, magnetohyperthermia can also be used as an adjuvant therapy to conventional cancer treatments by improving the efficacy of chemotherapy and radiotherapy. 2 A PLGA-MDDS formulation co-encapsulating maghemite nanoparticles and selol (MSE-NC) was recently developed, 16 aiming to provide a new antitumor therapy. Selol is a mixture of selenitetriglycerides synthesized from sunflower oil, containing selenium (+4) in its structure.…”

PEGylated poly(diselenide-phosphate) nanogel as efficient self-delivery nanomedicine for cancer therapy

“…[47][48][49] Here, these materials were adopted to construct the PEGylated poly(diselenide-phosphate) nanogel through the 'arm first' procedure. [47][48][49] Here, these materials were adopted to construct the PEGylated poly(diselenide-phosphate) nanogel through the 'arm first' procedure.…”

Thermal Potentiation of Chemotherapy by Magnetic Nanoparticles

“…cDDP-containing nanoparticles were found to be more cytotoxic in resistant and native A2780 cells. Other studies have also reported the release of cisplatin from magnetic nanoparticles [140,141] and other drugs, including bleomycin [142], concanavalin A [142], cyclophosphamide [143] and gemcitabine [144]. …”