An investigation of amphetamine-induced release of 5-HT from rat hippocampal slices

Balfour, David J.K.; Iyaniwura, Timothy T.

doi:10.1016/0014-2999(85)90401-7

Cited by 13 publications

(7 citation statements)

References 10 publications

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“…While, on the contrary, dopamine (DA) increases or decreases 3H-5-HT release in slices of rat hippocampus or in synaptosomes of rat nucleus accumbens, effects which are inhibited by dopamine receptor antagonists (Balfour and Iyaniwura, 1985). Therefore, the results obtained to date are not homogeneous, even for the 5-HT receptors.…”

Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

“…Serotonin release can be regulated by presynaptic receptors, either serotonergic (autoreceptors; Moret, 1985) or adrenergic, probably of the alpha, sub-type (Raiteri et al, 1983a), or dopaminergic (heteroreceptors; Balfour and Iyaniwura, 1985). In the former case, extensive research has attempted to characterize the subtype of the serotonergic receptor since in the human brain there is evidence for the existence of three major types of serotonin receptors termed 5-HTl-like, 5-HT2 and 5-HT3 (see Tables 1 and 2).…”

Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

“…Chronic administration of clonidine induces a 'down-regulation' of presynaptic alpha2-adrenoceptors regulating 3H-5-HT release in the rat brain (Maura et al, 1985). While, on the contrary, dopamine (DA) increases or decreases 3H-5-HT release in slices of rat hippocampus or in synaptosomes of rat nucleus accumbens, effects which are inhibited by dopamine receptor antagonists (Balfour and Iyaniwura, 1985). Therefore, the results obtained to date are not homogeneous, even for the 5-HT receptors.…”

Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

“…For example, DA inhibited the K+-stimulated release of [3H]5-HT from synaptosomes of the rat nucleus accumbens, this effect being antagonized by anti-psychotic drugs (sulpiride > haloperidol > clozapine) whereas methiothepine was ineffective (Drescher and Hetey, 1988). Once again the results are controversial, since in experiments performed in rat hippocampal slices by Balfour and Iyaniwura (1985) DA increased [3H]5-HT release, an effect blocked by DA antagonists.…”

Section: Dopaminergic Systemmentioning

confidence: 99%

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Pharmacology of serotonin neuronal systems

Ribeiro

1991

Hum. Psychopharmacol. Clin. Exp.

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PortugulThis review concerns the pharmacology of the serotonergic systems in the CNS. After the description of the anatomy of the serotonergic system the synthesis, release and inactivation of the neurotransmitter 5-HT is delineated. From the different serotonergic receptors (5-HTlA, S-HT,,, 5-HT,,, 5-HTID, 5-HT2 and 5-HT3) the current status with regard to available ligands, second messenger systems and physiological roles has been outlined. The last part of the review extends the relationship between the 5-HT and other neurotransmitter systems in the CNS (e.g. dopamine, noradrenaline, substance P, glutamate, acetylcholine and the opiates)

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Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

Section: Drugs Acting On Serotonin Releasementioning

confidence: 99%

Section: Dopaminergic Systemmentioning

confidence: 99%

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Pharmacology of serotonin neuronal systems

Ribeiro

1991

Hum. Psychopharmacol. Clin. Exp.

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“…Although DA contents are extremely low compared to 5-HT and noradrenaline (NA) levels (Verney et al 1985), several reports provided evidence that the hippocampal DA plays a functional role as neurotransmitters (Bishoff et al, 1979;Ishikawa et al 1982;Xu et al 1993). In vitro experiments using rat hippocampal slices showed that both spontaneous and K+-evoked F3H]-5-HT release were enhanced by the DA-releasing agent d-amphetamine (Balfour and Iyaniwura 1985). [3H]-5-HT release from synaptosomes prepared from the rat hippocampus was also increased by DA and apomorphine (Balfour and Clasper 1982).…”

Section: Introductionmentioning

confidence: 99%

Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: in vivo microdialysis study

Matsumoto

Yoshioka

Togashi

et al. 1996

Naunyn-Schmiedeberg's Arch Pharmacol

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The functional regulation by dopamine (DA) receptors of serotonin (5-HT) release from the rat hippocampus was investigated by use of in vivo microdialysis. Dialysate 5-HT levels were reduced by co-perfusion of 10 microM tetrodotoxin (TTX) and were elicited by K+ (60 and 120 mM) stimulation in a concentration-dependent manner. Local perfusion (10 microM) and peripheral administration (20 mg/kg, i.p.) of fluoxetine produced increases in 5-HT levels. These results indicate that the spontaneous 5-HT levels in the rat hippocampus can be used as indices of neuronal origin from the serotonergic nerve terminals. The nonselective dopamine (DA) receptor agonist apomorphine (1, 10 and 100 microM), when perfused through the probe over a period of 40 min, increased 5-HT release in a concentration-dependent manner. Apomorphine-induced (100 microM) increases in 5-HT release was abolished by pretreatment with the selective D2 receptor antagonist, S(-)-sulpiride (1 and 10 microM), but not prevented by pretreatment with the selective D1 receptor antagonist, R(+)-SCH-23390 (R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine) (1 microM). S(-)-Sulpiride and R(+)-SCH-23390 by themselves did not alter the spontaneous 5-HT levels. The 5-HT release was elevated by perfusion of the selective DA reuptake inhibitor GBR 12909 (1-[2-[bis(4-fluorophenyl) methoxy]ethyl]-4-[3-phenyl-propyl]piperazine) (1, 10 and 100 microM), indicating the possibility of not only exogenous but also endogenous DA-mediated facilitatory effects on 5-HT release in vivo. The 5-HT release was also elevated by perfused (+/-)-PPHT ((+/-)-2-(N-phenylethyl-N-propyl)-amino-5-hydroxytetralin) (1, 10 and 100 microM), the selective D2 receptor agonist, in a concentration-dependent manner. On the other hand, (+/-)-PPHT (100 microM) failed to increase 5-HT release in catecholamine (CA)-lesioned rats pretreated with 6-hydroxydopamine (6-OHDA)(200 micrograms/rat, i.c.v.). The (+/-)-PPHT-induced (100 microM) increase in 5-HT release was prevented not only by pretreatment with 10 microM S(-)-sulpiride but also by pretreatment with the alpha 2-adrenoceptor antagonist idazoxan (10 microM). These findings suggest that the functional regulation of 5-HT release via D2 receptors exists in the rat hippocampus. Furthermore our results indicate that the facilitatory effect of 5-HT release via D2 receptors may be mediated indirectly by noradrenergic neurons, but not mediated directly through D2 receptors located on serotonergic nerve terminals.

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5-Hydroxytryptamine involvement in the locomotor activity suppressant effects of amphetamine in the mouse

et al. 1987

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d-Amphetamine, in doses lower than required to increase motor activity, reduced mouse spontaneous locomotor activity when this was assessed using cages equipped with photocell units, using treadwheels, or the measurement of spontaneous climbing behaviour. Acute treatments with the serotonergic agonists quipazine and 5-hydroxy-DL-tryptophan also reduced wheel running activity, spontaneous locomotor activity assessed using photocell cages, and spontaneous climbing behaviour; fenfluramine caused a similar effect. Pretreatment with 5-hydroxy-DL-tryptophan enhanced the inhibitory effects of d-amphetamine. A 3-day treatment with fenfluramine, or lesions of the median raphe nucleus (but not the dorsal raphe nucleus) abolished the ability of d-amphetamine to reduce motor activity in the three test systems. It is concluded that low doses of d-amphetamine can reduce locomotor activity and that the effects may be mediated via an enhancement of the release of 5-hydroxytryptamine from the system arising in the median raphe nucleus.

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An investigation of amphetamine-induced release of 5-HT from rat hippocampal slices

Cited by 13 publications

References 10 publications

Pharmacology of serotonin neuronal systems

Pharmacology of serotonin neuronal systems

Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: in vivo microdialysis study

5-Hydroxytryptamine involvement in the locomotor activity suppressant effects of amphetamine in the mouse

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