An investigation of bioactive phytochemicals in the leaves of Melicope vitiflora by electrospray ionisation ion trap mass spectrometry

O'Donnell, F.R.; Ramachandran, V. N.; Smyth, Thomas J.; Smyth, W. Franklin; Brooks, Peter

doi:10.1016/j.aca.2008.11.066

Cited by 15 publications

(6 citation statements)

References 18 publications

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“…Nowadays several efficient analytical methods (e.g HPLC, HPTLC, high speed countercurrent chromatography) for the selective separation, detection and quantification of 7-isopentenyloxycoumarin in plant extracts are also available [30,39,[44][45][46][47][48].…”

Section: Natural and Synthetic Sourcesmentioning

confidence: 99%

Insights on Novel Biologically Active Natural Products: 7-Isopentenyloxycoumarin

Epifano

Pelucchini

Curini

et al. 2009

Natural Product Communications

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7-Isopentenyloxycoumarin is a prenyloxyphenylpropanoid derivative found in low concentration in a restricted number of plant families (Apiaceae, Asteraceae, and Rutaceae). Synthetic schemes were recently developed enabling sufficient quantities of the title coumarin to be obtained in order to evidence its valuable biological effects, mainly as an anti-cancer agent. The aim of this review is to examine the phytochemical and pharmacological properties of this compound.

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Section: Natural and Synthetic Sourcesmentioning

confidence: 99%

Insights on Novel Biologically Active Natural Products: 7-Isopentenyloxycoumarin

Epifano

Pelucchini

Curini

et al. 2009

Natural Product Communications

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“…An ethyl acetate extract of M. vitiflora, a plant genetically close to M. latifolia, was reported to possess antibacterial activities against methicillin-resistant Staphylococcus aures and Micrococcus luteus [18] . The authors identified some compounds contained in the extract, including coumarin and terpenoid compounds.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus

Wahyuni

Tumewu

Permanasari

et al. 2013

Virol J

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BackgroundHepatitis C virus (HCV) is a major cause of liver disease and a potential cause of substantial morbidity and mortality worldwide. The overall prevalence of HCV infection is 2%, representing 120 million people worldwide. Current standard treatment using pegylated interferon and ribavirin is effective in only 50% of the patients infected with HCV genotype 1, and is associated with significant side effects. Therefore, it is still of importance to develop new drugs for treatment of HCV. Antiviral substances obtained from natural products, including medicinal plants, are potentially good targets to study. In this study, we evaluated Indonesian medicinal plants for their anti-HCV activities.MethodsEthanol extracts of 21 samples derived from 17 species of medicinal plants explored in the East Java region were tested. Anti-HCV activities were determined by a cell culture method using Huh7.5 cells and HCV strains of 9 different genotypes (1a to 7a, 1b and 2b).ResultsFour of the 21 samples tested showed antiviral activities against HCV: Toona sureni leaves (TSL) with 50% inhibitory concentrations (IC50) of 13.9 and 2.0 μg/ml against the HCV J6/JFH1-P47 and -P1 strains, respectively, Melicope latifolia leaves (MLL) with IC50 of 3.5 and 2.1 μg/ml, respectively, Melanolepis multiglandulosa stem (MMS) with IC50 of 17.1 and 6.2 μg/ml, respectively, and Ficus fistulosa leaves (FFL) with IC50 of 15.0 and 5.7 μg/ml, respectively. Time-of-addition experiments revealed that TSL and MLL inhibited both at the entry and post-entry steps while MMS and FFL principally at the entry step. TSL and MLL inhibited all of 11 HCV strains of all the genotypes tested to the same extent. On the other hand, FFL showed significantly weaker inhibitory activities against the HCV genotype 1a strain, and MMS against the HCV strains of genotypes 2b and 7a to a lesser extent, compared to the other HCV genotypes.ConclusionsEthanol extracts of TSL, MLL, MMS and FFL showed antiviral activities against all the HCV genotypes tested with the exception that some genotype(s) showed significant resistance to FFL and to MMS to a lesser extent. These plant extracts may be good candidates for the development of anti-HCV drugs.

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“…Sự tăng sinh của nguyên bào sợi và tế bào keratin đóng vai trò quan trọng trong pha tăng sinh của quá trình lành vết thương. Kích thích tăng sinh hai loại tế bào này giúp nhanh chóng làm liền miệng vết thương cũng như phục hồi cấu trúc và chức năng của da bị tổn thương [26,27]. Để kiểm tra hoạt tính kích thích tang sinh tế bào keratin và nguyên bào sợi của cây ba chạc, chúng tôi thực hiện đánh giá khả năng kích thích tăng sinh hai dòng tế bào NIH3T3 và HaCaT bằng phương pháp MTT.…”

Section: Trang 30unclassified

Evaluating the wound healing ability of Melicope pteleifolia (Champ. Ex Benth.) T.g. Hartley

Nguyen¹,

Nguyen²,

Tran³

et al. 2017

Sci. Tech. Dev. J. - Nat. Sci.

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Melicope pteleifolia (Champ. ex benth.) T.g. Hartley, a folk medicinal plant, is used by ethnic minorities in Bidoup–Nui Ba National Park, Lam Dong Province, Vietnam to treat effectively wound, inflammation and skin ulcer. To scientifically prove the claimed utilization and understand the mechanism of action of the plant, the in vitro and in vivo healing properties of the extract and fractions of the plant were investigated. The ethanol 70 % extract (50 – 400 mg/mL), aqueous (200 mg/mL), ethyl acetate (100 mg/mL) and petroleum ether (50 mg/mL) fractions were used to evaluate the antibacterial activities by using agar diffusion method. The healing properties were in vitro investigated through fibroblasts and keratinocytes proliferation and migration (7.8 g/mL to 250 g/mL in accordance with each extract and fraction). Besides, the macrophage-induced inhibition of the nitric oxide (NO) production was examined (15.6 – 62.5 g/mL). In addition, the excision wound model was used to test the wound healing activity on mice model. We found that the ethanol extract and the ethyl acetate fraction showed potent activity against Staphylococcus aureus, Enterococcus feacalis and Pseudomonas aeruginosa. The extract and fractions stimulated fibroblasts and keratinocytes proliferation in a concentration-dependent way. They also inhibited macrophage produce NO. In addition, mice treated by the extract formed scabs on wound excision of mice model faster than the control group. The wound healing efficiency seems to involve antibacterial, stimulating fibroblasts and keratinocytes proliferation, inhibition of macrophages produce NO.

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An investigation of bioactive phytochemicals in the leaves of Melicope vitiflora by electrospray ionisation ion trap mass spectrometry

Cited by 15 publications

References 18 publications

Insights on Novel Biologically Active Natural Products: 7-Isopentenyloxycoumarin

Insights on Novel Biologically Active Natural Products: 7-Isopentenyloxycoumarin

Antiviral activities of Indonesian medicinal plants in the East Java region against hepatitis C virus

Evaluating the wound healing ability of Melicope pteleifolia (Champ. Ex Benth.) T.g. Hartley

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