Digitalization is rushing throughout the world, namely, in industrial and societal infrastructures. Hence, digital transformation becomes a pillar of industrial policy, known in Europe as “Industry 4.0,” in China as “made in China 2025,” in Asia as “Smart Cities,” in Japan as “Society 5.0,” and in North America as “Industrial Internet.” These transformations will change the industrial landscape, toward Quality 4.0 and therefore, our lives. The presented research was conducted on quality management employees in Portugal and it aims to analyze if such employees have the perception of the impact of Industry 4.0 in the quality management profession and the required and needed skills. After analyzing the answered questionnaires, 90 results were considered valid. This is the sample of our study. Simultaneously, the goal of this research is also to review and analyze the main topics in progress related to quality management for the fourth industrial revolution and how quality emerges of this change. The professionals that work on quality management must have creative thinking, be leaders, know how to communicate and work as a team, as well as, to have knowledge and understanding of ICT (Information and Communications Technology), and main pillars of Industry 4.0. These are the main findings. Besides that, they must know how to motivate their work teams, be open to change, know how to use Big Data to make decisions and above all, they must know how to manage conflicts. In addition, quality professionals must promote the design and production of first class products, be the defenders of their customers within the organization, and finally, they must create value for the stakeholders.