The multi-lip combined seal has the advantages of multi-lip coupling, large supporting force, and can withstand high-pressure shocks. It is an irreplaceable structure for single-lip seals. However, most of the seal wear analysis focuses on the simulation method of the single-lip seal under the influence of macro factors, and very little involves the wear characteristics of multi-lip seals. In this paper, a micro numerical method is established, which combines the elastohydrodynamic lubrication theory with the modified Archard equation. The performance of a multi-lip combined seal under different working conditions is analyzed through simulation, including macro and micro factors. It is found that some of the characteristics of single-lip seals are also reflected in multi-lip seals, and there is a critical speed that makes the sealing behavior of each seal lip different.