Online courses allow students to access the course materials anytime and anywhere. Those courses are meant to enhance and improve the learning processes. Unfortunately, by analyzing data of an online course in Al-Ahliyya Amman University, it was found that only 51% of enrolled students accessed the animated course material. This study proposed a model to understand the factors which affect students' intention to use an online course by extending the Unified Theory of Acceptance and Use of Technology (UTAUT) and Technology Acceptance Model (TAM). The proposed research model investigated the effects of experience, perceive usefulness, awareness, effort expectancy, cost, subjective (social) norms, and behavioral intentions to use online courses on students' adoption of online courses. Besides, the model investigated the effects of moderators, such as: college, college level, personal computer ownership, an internet access, and an online course enrollment on the relations. A questionnaire was distributed and then a structural equation modeling (SEM) approach was used to analyze the responses using SmartPLS.