An investigation of the flow field within patient-specific models of an abdominal aortic aneurysm under steady inflow conditions

O'Rourke, Malachy; McCullough, James P.

doi:10.1243/09544119jeim694

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…This is primarily due to the simplicities both in generating the steady flow in a circulatory loop and in performing flow measurements in such systems. In that sense, many experimental studies have been conducted at steady flow conditions using different type of flow generators, such as variable speed centrifugal or gear pumps (Ku et al, 1989; Asbury et al, 1995; Bluestein et al, 1996; Boutsianis et al, 2008), steady submersible pumps (Chen et al, 2014, 2015) or sometimes, by only using the effect of gravity, which requires placing a head tank (O'Rourke and McCullough, 2010).…”

Section: Experimental Investigation Of Hemodynamics Of Aaasmentioning

confidence: 99%

Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques

Salman

Ramazanlı

Yavuz

et al. 2019

Front. Bioeng. Biotechnol.

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Abdominal aortic aneurysm (AAA) is the dilatation of the aorta beyond 50% of the normal vessel diameter. It is reported that 4–8% of men and 0.5–1% of women above 50 years of age bear an AAA and it accounts for ~15,000 deaths per year in the United States alone. If left untreated, AAA might gradually expand until rupture; the most catastrophic complication of the aneurysmal disease that is accompanied by a striking overall mortality of 80%. The precise mechanisms leading to AAA rupture remains unclear. Therefore, characterization of disturbed hemodynamics within AAAs will help to understand the mechanobiological development of the condition which will contribute to novel therapies for the condition. Due to geometrical complexities, it is challenging to directly quantify disturbed flows for AAAs clinically. Two other approaches for this investigation are computational modeling and experimental flow measurement. In computational modeling, the problem is first defined mathematically, and the solution is approximated with numerical techniques to get characteristics of flow. In experimental flow measurement, once the setup providing physiological flow pattern in a phantom geometry is constructed, velocity measurement system such as particle image velocimetry (PIV) enables characterization of the flow. We witness increasing number of applications of these complimentary approaches for AAA investigations in recent years. In this paper, we outline the details of computational modeling procedures and experimental settings and summarize important findings from recent studies, which will help researchers for AAA investigations and rupture mechanics.

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Section: Experimental Investigation Of Hemodynamics Of Aaasmentioning

confidence: 99%

Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques

Salman

Ramazanlı

Yavuz

et al. 2019

Front. Bioeng. Biotechnol.

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“…The patient-based geometries described in this article were selected and generated by Dr James McCullough during work carried out in Dartmouth College, Hanover, NH. 20,21 Secured release was obtained from the patients involved. For each geometry, computerised tomography (CT) was used to produce a series of overlapping slices of 2.5 mm thickness.…”

Section: Geometry Creationmentioning

confidence: 99%

“…During work carried out in University College Dublin, McCullough 20,21 built experimental models of these geometries and used flow visualisation and laser Doppler velocimetry (LDV) to examine the unsteady flow patterns within each model. Rapid prototyping was performed on the STL files and silicon moulds were produced by suspending the rapid prototype models in boxes and pouring silicon around them.…”

Section: Geometry Creationmentioning

confidence: 99%

Fluid, solid and fluid–structure interaction simulations on patient-based abdominal aortic aneurysm models

Kelly

O'Rourke

2012

Proc Inst Mech Eng H

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This article describes the use of fluid, solid and fluid-structure interaction simulations on three patient-based abdominal aortic aneurysm geometries. All simulations were carried out using OpenFOAM, which uses the finite volume method to solve both fluid and solid equations. Initially a fluid-only simulation was carried out on a single patient-based geometry and results from this simulation were compared with experimental results. There was good qualitative and quantitative agreement between the experimental and numerical results, suggesting that OpenFOAM is capable of predicting the main features of unsteady flow through a complex patient-based abdominal aortic aneurysm geometry. The intraluminal thrombus and arterial wall were then included, and solid stress and fluid-structure interaction simulations were performed on this, and two other patient-based abdominal aortic aneurysm geometries. It was found that the solid stress simulations resulted in an under-estimation of the maximum stress by up to 5.9% when compared with the fluid-structure interaction simulations. In the fluid-structure interaction simulations, flow induced pressure within the aneurysm was found to be up to 4.8% higher than the value of peak systolic pressure imposed in the solid stress simulations, which is likely to be the cause of the variation in the stress results. In comparing the results from the initial fluid-only simulation with results from the fluid-structure interaction simulation on the same patient, it was found that wall shear stress values varied by up to 35% between the two simulation methods. It was concluded that solid stress simulations are adequate to predict the maximum stress in an aneurysm wall, while fluid-structure interaction simulations should be performed if accurate prediction of the fluid wall shear stress is necessary. Therefore, the decision to perform fluid-structure interaction simulations should be based on the particular variables of interest in a given study.

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“…Computational studies have looked at flow phenomena in different areas of the circulation, Chiulli et al (2012) such as pulsatile flow in the carotid artery bifurcation (Perktold et al 1991) and the way in which endothelial cells are stimulated by fluid forces (Satcher et al 1992). CFD models have become more refined with increasing computational power and recent work covers different areas, including cerebral and abdominal aneurysms (Cebral et al 2011;O'Rourke and McCullough 2010), coronary circulation (Chaichana et al 2011), congenital heart disease (Ladisa et al 2010;Qian et al 2010) and cardiac assist devices (Filipovic and Schima 2011;Medvitz et al 2007). An example is shown in Fig.…”

Section: In Silico Modelingmentioning

confidence: 99%

Cardiovascular Modeling

Biglino¹,

Schievano²,

Muthurangu³

et al. 2011

Clinical Cardiac MRI

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An investigation of the flow field within patient-specific models of an abdominal aortic aneurysm under steady inflow conditions

Cited by 8 publications

References 18 publications

Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques

Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques

Fluid, solid and fluid–structure interaction simulations on patient-based abdominal aortic aneurysm models

Cardiovascular Modeling

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