2018
DOI: 10.1039/c7ra12104k
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An investigation on 3-acetyl-7-methoxy-coumarin Schiff bases and their Ru(ii) metallates with potent antiproliferative activity and enhanced LDH and NO release

Abstract: New cyclometallated ruthenium(ii) complexes of 3-acetyl-7-methoxycoumarin-4N-substituted thiosemicarbazones were synthesized and characterized by analytical and spectral techniques.

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Cited by 32 publications
(36 citation statements)
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“…We can also observe a decrease in peak 2, which indicates changes in the peptide structure. Its declining trend after conazoles binding suggests that there is a slight destabilization of individual proteins and a slight unfolding of the polypeptide chain leading to conformational changes [58]. This result correlates with absorption and CD spectroscopy measurements.…”
Section: Three-dimensional Fluorescence Spectroscopysupporting
confidence: 75%
“…We can also observe a decrease in peak 2, which indicates changes in the peptide structure. Its declining trend after conazoles binding suggests that there is a slight destabilization of individual proteins and a slight unfolding of the polypeptide chain leading to conformational changes [58]. This result correlates with absorption and CD spectroscopy measurements.…”
Section: Three-dimensional Fluorescence Spectroscopysupporting
confidence: 75%
“…These experimental results were also seen in other Schiff base complexes in the literature. [ 60,61 ]…”
Section: Resultsmentioning
confidence: 99%
“…The observed hypochromism and blue shift indicated the interaction of Ru/Fe complexes with BSA molecules and changes in the local environment of the fluorophore. [ 49,50 ] The fluorescence quenching constant is described by the Stern–Volmer equation [ 51a ] : Io/I=1+KSV[]Q …”
Section: Resultsmentioning
confidence: 99%
“…The observed hypochromism and blue shift indicated the interaction of Ru/Fe complexes with BSA molecules and changes in the local environment of the fluorophore. [49,50] The fluorescence quenching constant is described by the Stern-Volmer equation [51a] : obtained on analysis of the Stern-Volmer quenching constant ( Table 4) and indicated that all the complexes had a single quenching mechanism.…”
Section: Bsa Binding Studiesmentioning
confidence: 99%