The ultimate aim of the article is to predict COVID-19 virus inter-cellular behavioral dynamics using an infection model with a quarantine compartment. Internal viral dynamics and stability attributes are thoroughly investigated around stable equilibrium states to probe possible ways in reducing rapid spread by incorporating fractional-order components into epidemic systems. Furthermore, a fractional optimal problem was built and studied with three control measures to restrict the widespread of COVID-19 infections and exhibit perfect protection. It is found that by following
of control strategies can eradicate the infectives. Furthermore, the time frame of sixteen months has been divided into four short periods to grasp the pandemic, as the pandemic’s parameters change over time. Finally, using real data, we estimated the parameters of the model system and the expression of the basic reproduction number
for the most affected countries, China, USA, UK, Italy, France, Germany, Spain, and Iran.