An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor

Alemdaroğlu, Ceren; Değim, Zelihagül; Çelebi, Nevin; Zor, Fatih; Öztürk, Serdar; Erdoğan, Deniz

doi:10.1016/j.burns.2005.10.015

Cited by 278 publications

(151 citation statements)

References 34 publications

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“…Useful growth factors for wound healing are epidermal growth factor (EGF) (Alemdaroğlu et al, 2006), basic fibroblast growth factor (bFGF) (Mizuno et al, 2003;Park et al, 2009), fibroblast growth factor-2 (FGF-2) (Obara et al, 2005), transforming growth factor-beta (TGF-β) (Gopal et al, 2014), platelet-derived growth factor (PDGF) (Judith et al, 2010), and vascular endothelial growth factor (VEGF) (Frank et al, 1995).…”

Section: Hydrogels and Growth Factor Deliverymentioning

confidence: 99%

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Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

487

215

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Abstract:Chitosan and its derivatives have attracted great attention due to their properties beneficial for application to wound healing. The main focus of the present review is to summarize studies involving chitosan and its derivatives, especially N,N,N-trimethylchitosan (TMC), N,O-carboxymethyl-chitosan (CMC) and O-carboxymethyl-N,N,Ntrimethyl-chitosan (CMTMC), used to accelerate wound healing. Moreover, formulation strategies for chitosan and its derivatives, as well as their in vitro, in vivo and clinical applications in wound healing are described.

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Section: Hydrogels and Growth Factor Deliverymentioning

confidence: 99%

“…Alemdaroğlu et al (Alemdaroğlu et al, 2006) developed a chitosan gel for topical administration of EGF in the treatment of second degree burns. The gel released EGF completely over 24 hours.…”

Section: Hydrogels and Growth Factor Deliverymentioning

confidence: 99%

Chitosan as a starting material for wound healing applications

Patrulea

Ostafe

Borchard

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

487

215

View full text Add to dashboard Cite

show abstract

“…The functionality of chitosan is thus directly linked to free amino groups and to hydroxyl. The positive charge allows many electrostatic interactions of chitosan with negatively charged molecules [22,23]. Chitosan can be characterized by taking into account physical, chemical and biological properties and the physical properties studied are particle size, solubility, density, viscosity and description of their presentations.…”

Section: Chitosan and Its Derivatives: Physical Chemical And Biologimentioning

confidence: 99%

Application of Chitosan and Buriti Oil (Mauritia Flexuosa L.) in Skin Wound Healing

Rfj

Pighinelli

2017

JABB

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Wound is the breakdown of the structure and normal functions of the integument and its healing process. The wound healing process is common to all tissues and is characterized by three stages: inflammation, proliferation (fibroblast phase) and remodelling. Many substances are used to improve and accelerate this process. A polymer that comes to the attention of researchers is chitosan, which is obtained by the deacetylation of chitin. Another substance that shows good results in the healing process is buriti oil, extracted mainly from the fruit bulb of Mauritia flexuosa L. The main objective of this study is to demonstrate through bibliographical research the effects of chitosan and buriti oil on healing, as well as describing the process of obtaining chitosan and buriti oil and characterizing chitosan and buriti oil. This is an exploratory study where the bibliographical review was used as technical procedure. For the elaboration of the study, we used scientific materials already published, consisting mainly of theses, dissertations, books, articles of scientific journals and annals of scientific congresses, observing the temporal limits between 2000 and 2016. A potential use of chitosan and oil of buriti in the healing of cutaneous wounds since they presented good results in all the phases of tissue repair. Chitosan has been characterized as being biodegradable, biocompatible has free amine groups thus becoming well reactive, the oil has an orange-coloured liquid, rich in carotenoids (β-carotene), α-tocopherol (vitamin E) And fatty acids. It is expected that this study can serve as a reference for studies on these substances, as well as that they can be used together in order to potentiate their effects on the healing process.

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“…The findings were overlapped by Balazzi et al [1], Azuma et al [4], Usami et al al. [12], Da silva et al [14], Alemdaroglu et al [18] and Sezer et al [19]. Post traumatic hemorrhage remains one of the most mortal causes of early death with progressive seconder infections in wounds.…”

Section: Recoverymentioning

confidence: 99%

Canine Extremity Wound Treatment with Chitosan Extracted from Shrimp Shells: A Case Report

Tekelioğlu¹,

Çeli̇k²,

Yandim³

2017

JAST-A

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Abstract:The aim of this case report was to demonstrate the effectivity of chitosan as topical agent on the treatment of severely infected canine extremity wound. The dog was hit by a bus and presented severe friction wounds accompanying with bilateral hip and extremity fractures. Local and generalized infections were observed on the post operational period. The dog was unresponsive to the standard therapeutic protocols and health status was getting worsened. The regenerative sutures did not hold the tissues because of the infection and the tissue eruption. Chitosan samples were extracted from shrimp shell wastes. The milled form of chitosan was topically used to treat the open and heavily mix infected wound areas located at skin and rear extremities accompanying with fever and Canine coronavirus diarrhea. It was decided to use the chitosan as a bio barrier and anti-bio affect over the damaged and erupted tissues. Macroscopic findings indicated chitosan promoted the natural blood clotting and absorbed the inflammation fluid. Microscopic findings indicated the infiltration of polymorph nuclear leukocytes (PMN) accelerated with the topical use of chitosan in the early phase of wound healing. The wound healing was observed daily. This veterinary practice wound treatment result indicated that chitosan is effective to medicate topically the canine open and mix infected wounds with bacteria and viruses and promotes the granulomatosis in four weeks period.

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An investigation on burn wound healing in rats with chitosan gel formulation containing epidermal growth factor

Cited by 278 publications

References 34 publications

Chitosan as a starting material for wound healing applications

Chitosan as a starting material for wound healing applications

Application of Chitosan and Buriti Oil (Mauritia Flexuosa L.) in Skin Wound Healing

Canine Extremity Wound Treatment with Chitosan Extracted from Shrimp Shells: A Case Report

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