An Investigation on the Antibacterial and Antibiofilm Efficacy of Cationic Nanoparticulates for Root Canal Disinfection

Kishen, Anil; Shi, Zhijun; Shrestha, Annie; Neoh, K. G.

doi:10.1016/j.joen.2008.08.035

Cited by 245 publications

(199 citation statements)

References 25 publications

Supporting

Mentioning

178

Contrasting

Unclassified

Order By: Relevance

“…Antibacterial nanoparticles exhibit higher antibacterial activity than antibacterial powders because of their greater surface area and charge density, which allows greater interaction with the negatively charged surface of bacterial cells. Kishen et al 43 highlighted the potential advantage of cationic nanoparticles in root canal disinfection.…”

Section: Nanotechnology and Dental Applicationsmentioning

confidence: 99%

Nanotechnology in Dentistry

Arruda¹,

Oliveira²,

Paula³

et al. 2017

Arch Health Invest

View full text Add to dashboard Cite

Introduction: Nanotechnology is a rapidly expanding field that encompasses the development, manipulation, and application of structures on the nanometer scale. Applications of nanotechnology to dentistry are particularly promising and comprise materials and devices designed to achieve maximal therapeutic efficacy with minimal side effects. Objective: This review discusses the advantages of nanotechnology and the different types of nanostructures used in dentistry. Material and Method: In this study, online databases: pubmed, medline and scielo were searched to analyse the current understanding of the potential of nanotechnology in dentistry, including the restoration of tooth structure with nanocomposites and the development of nanoparticles for dentin remineralisation, drug delivery, disease diagnostics, oral analgesia, oral hygiene maintenance, local anaesthesia, tooth desensitisation, and bone tissue repair. Results: The study demonstrated a wide range of nanotechnological strategies in different dentistry areas and suggests that nanotechnology-based delivery systems may be very useful to improve treatment, prevention and repair in dentistry in the future. Conclusion: There is little or no clinical experience for the nanotechnology-based drug delivery systems cited herein. Safety assessments and clinical trials are the next step in their development.

show abstract

Section: Nanotechnology and Dental Applicationsmentioning

confidence: 99%

Nanotechnology in Dentistry

Arruda¹,

Oliveira²,

Paula³

et al. 2017

Arch Health Invest

View full text Add to dashboard Cite

show abstract

“…Collagen is the main structural protein of the dentin matrix, increase in collagen cross-linking increases the mechanical properties of dentin in infectious condition inside the canal. 89 Two mechanisms have a major role in lethal damage administered by PDT, (i) DNA damage, (ii) damage to cytoplasmic membrane and cellular contents or inactivation of membrane transport systems and enzymes. 90 It seems that the DNA damage is a more important mechanism for PDT of bacteria.…”

Section: Mechanism Of Photodynamic Therapymentioning

confidence: 99%

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

et al. 2015

View full text Add to dashboard Cite

The main goal in endodontic treatment is to eradicate or at least reduce intraradicular microbial population to levels that are more compatible with periapical lesions healing process. Since endodontic infections are polymicrobial in nature, intraradicular survival of endodontic microbiota and their pathogenic properties are influenced by a combination of their virulence factors. The purpose of this article is to review the endodontic microbiota and their respective virulence attributes, as well as perform a literature review of the effects of disinfection procedures in the treatment of endodontic infections to gain best practices. Conventional technique for root canal preparation includes mechanical debridement and application of antimicrobial irrigants. Recently, laser irradiation has been used to enhance the results of root canal treatment through its thermal effect. To reduce thermal side effects, laser activated irrigation (LAI) and photon induced photoacoustic streaming (PIPS) were introduced. Antimicrobial photodynamic therapy (aPDT) by photochemical reaction uses light at a specific wavelength to activate a nontoxic photosensitizer (PS) in the presence of oxygen to produce cytotoxic products. Different PSs are used in dentistry including methylene blue (MB), toluidine blue O (TBO), indocyanine green (ICG) and curcumin. Among different options, ICG could be the best choice due to its peak absorption at wavelength of 808 nm, which coincides with the commercial diode laser devices. Also, this wavelength has more penetration depth compared to other wavelengths used in aPDT.

show abstract

“…This has been attributed to the broad spectrum of spectrum antibacterial activity [26,27]. The nanoparticles evaluated on endodontics include Chitosan, zinc oxide and silver [28,29].…”

Section: Nanoparticulate Based Disinfection In Endodonticsmentioning

confidence: 99%

“…The efficacy of chitosan and zinc oxide nanoparticles against Enterococcus fecalis has been attributed to their ability to disrupt the cell wall. In addition, these nanoparticles are also able to disintegrate the biofilms within the root canal system [26,29,30]. Silver nanoparticles are being evaluated for use as root canal disinfecting agents.…”

Section: Nanoparticulate Based Disinfection In Endodonticsmentioning

confidence: 99%

Nanotechnology In Dentistry - What Does The Future Hold In Store?

P¹

2014

Dentistry

View full text Add to dashboard Cite

The medical and dental field has seen several technological revolutions that have changed clinical practice. One concept which has and holds further promise in bringing about a paradigm shift in the field of diagnostics and management is nanotechnology. Nanotechnology has several applications in dentistry, from diagnosis of pathological conditions to local anaesthesia, orthodontic tooth movement and periodontics. Biomaterials science has also greatly benefited by this technology. This review provides a comprehensive discussion of the present and future of nanotechnology in dentistry.

show abstract

An Investigation on the Antibacterial and Antibiofilm Efficacy of Cationic Nanoparticulates for Root Canal Disinfection

Cited by 245 publications

References 25 publications

Nanotechnology in Dentistry

Nanotechnology in Dentistry

Clinical Approach of High Technology Techniques for Control and Elimination of Endodontic Microbiota

Nanotechnology In Dentistry - What Does The Future Hold In Store?

Contact Info

Product

Resources

About