An investigation on the anticandidal activity of some traditional medicinal plants in Turkey

Yiğit, Demet; Yiğit, Nimet; Ozgen, Ufuk

doi:10.1111/j.1439-0507.2008.01552.x

Cited by 21 publications

(15 citation statements)

References 25 publications

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“…3). Although we observed antifungal activity against Candida albicans only in a chloroform fraction (CE 10b), our results agree with published work that reported no activity of the MEE of Galium verum (Yigit et al, 2008).…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

Bolívar

Cruz-Paredes

Hernández

et al. 2011

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 92%

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

Bolívar

Cruz-Paredes

Hernández

et al. 2011

Journal of Ethnopharmacology

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“…Nevertheless, Bolivar et al (2011) studied G. mexicanum extracts and fractions and demonstrated the ability of some hexane and methanol fractions to inhibit the growth of Trichophyton rubrum and Cryptococcus neoformans, when concentrated at 333-500 and 333-999 μg/mL, respectively, while a chloroform fraction exhibited activity in Candida albicans at 666 μg/mL; none of the assessed extracts (chloroform and methanol extracts) revealed antimicrobial properties. Similarly, G. verum methanolic extracts did not reveal antifungal activity in a study performed with several Candida species (Yiǧit et al, 2009), contrarily to G. aparine hydromethanolic extracts assessed in the present study that showed the capacity to inhibit the growth of eight fungi, also revealing fungicidal properties.…”

Section: Antimicrobial Activitycontrasting

confidence: 68%

Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.

Senio

Pereira

Vaz

et al. 2018

Industrial Crops and Products

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A B S T R A C TGalium aparine L. is a very disseminated plant in temperate zones, commonly known as clivers or bedstraw, belonging to the Rubiaceae family and it is traditionally used for its medicinal applications. In this study, G. aparine hydromethanolic extracts and infusions were prepared from air-dried and freeze-dried samples in order to assess their phenolic profile, antioxidant, antimicrobial, and cytotoxic properties. All the studied extracts revealed a similar phenolic profile, but the hydromethanolic extract obtained from the freeze-dried sample presented the highest concentration of phenolic compounds, followed by the respective infusion and the airdried sample hydromethanolic extract. The major compound detected in the extracts was 5-O-caffeoylquinic acid (from 145 to 163 mg/g extract). Regarding the bioactivity, in general, the extracts presenting higher phenolic concentrations also revealed enhanced bioactive properties. The EC 50 values obtained in the antioxidant activity assays ranged from 13.5 to 884 μg/mL, with the freeze-dried sample hydromethanolic extract presenting the highest activity (13.5-555 μg/mL). Similar conclusions could be made in terms of antimicrobial properties, with this extract showing the lowest MIC (1.85-15 mg/mL), MBC (3.75-7.5 mg/mL), and MFC (3.75-20 mg/mL) values. None of the extracts revealed cytotoxicity. The results obtained in this study suggested that G. aparine extracts can be a good source of phenolic compounds with antioxidant and antimicrobial properties.

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“…Other important activities of EOMS include protective effects against hydrogen-peroxide-induced-cytotoxicity. Anti- Candida activity has been described for Mentha piperita [29]. Furthermore EOMS was effective against Gram positive and Gram negative microorganisms and fungi [13].…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection

Pietrella

Angiolella

Vavala

et al. 2011

BMC Complement Altern Med

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BackgroundVaginal candidiasis is a frequent and common distressing disease affecting up to 75% of the women of fertile age; most of these women have recurrent episodes. Essential oils from aromatic plants have been shown to have antimicrobial and antifungal activities. This study was aimed at assessing the anti-fungal activity of essential oil from Mentha suaveolens (EOMS) in an experimental infection of vaginal candidiasis.MethodsThe in vitro and in vivo activity of EOMS was assessed. The in vitro activity was evaluated under standard CLSI methods, and the in vivo analysis was carried out by exploiting a novel, non-invasive model of vaginal candidiasis in mice based on an in vivo imaging technique.Differences between essential oil treated and saline treated mice were evaluated by the non-parametric Mann-Whitney U-test. Viable count data from a time kill assay and yeast and hyphae survival test were compared using the Student's t-test (two-tailed).ResultsOur main findings were: i) EOMS shows potent candidastatic and candidacidal activity in an in vitro experimental system; ii) EOMS gives a degree of protection against vaginal candidiasis in an in vivo experimental system.ConclusionsThis study shows for the first time that the essential oil of a Moroccan plant Mentha suaveolens is candidastatic and candidacidal in vitro, and has a degree of anticandidal activity in a model of vaginal infection, as demonstrated in an in vivo monitoring imaging system. We conclude that our findings lay the ground for further, more extensive investigations to identify the active EOMS component(s), promising in the therapeutically problematic setting of chronic vaginal candidiasis in humans.

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An investigation on the anticandidal activity of some traditional medicinal plants in Turkey

Cited by 21 publications

References 25 publications

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

Antimicrobial, anti-inflammatory, antiparasitic, and cytotoxic activities of Galium mexicanum

Dehydration process influences the phenolic profile, antioxidant and antimicrobial properties of Galium aparine L.

Beneficial effect of Mentha suaveolens essential oil in the treatment of vaginal candidiasis assessed by real-time monitoring of infection

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