Abstract-Network-on-Chip (NoC) paradigm has been proposed as an alternative bus-based schemes to achieve high performance and scalability in System-on-Chip (SoC) design. Performance analysis and evaluation of on-chip interconnect architectures are widely considered. Time latency and throughput are two very critical parameters which play vital role to improve the system performance. In this work, these two elements are evaluated in both wire and wireless approaches under different conditions for networks contain 64,512 and 1024 number of cores. There are number of parameters those have direct and indirect effects on the delay and throughput, among all, these four are chosen: routing algorithm, buffer size, virtual channel and subnet. Thus this work is clustered into two general parts, in the first section the effect of algorithms and buffer size are calculated and then later on in second part when switching from wire approach to wireless, it's shown that, virtual channel and subnet are able to influence the performance of a network on chip positively under some circumstances. We don't concentrate on approach and techniques here. Our target in this paper is to determine the critical points, trade-off and study the effect of mentioned parameters on entire system. Evaluation is done by means of Booksim and Noxim simulators which are based on system C.