We examine the impact of the glass network-modifier cation field strength (CFS) on ion irradiation-induced mechanical property changes in borosilicate (BS) glasses for the ternary M 2 O-B 2 O 3 -SiO 2 systems with M = {Na, K, Rb} and the quaternary [0.5M (2) O-0.5Na 2 O]-B 2 O 3 -SiO 2 systems with M = {Li, Na, K, Rb Mg, Ca, Sr, Ba}. 11 B nuclear magnetic resonance (NMR) experiments on the as-prepared BS glasses yielded the fractional population of four-coordinated B species (B [4] ) out of all {B [3] , B [4] } groups in the glass network, along with the fraction of B [4] -O-Si linkages out of all B [4] -O-Si/B bonds. Both parameters correlated linearly with the (average) CFS of the M + and/or {M (2)+ , Na + } cations. Both the nanoindentation-derived hardness and Young's modulus values of the glasses reduced upon their irradiation by Si 2+ ions, with the property deterioration decreasing linearly with increasing M z+ CFS, that is, for higher M z+ ⋯O interaction strength. The irradiation damage of the glass network also increased linearly with the fraction of B [4] -O-Si linkages, which are the second weakest in the structure after the M z+ ⋯O bonds. Our results underscore the advantages of employing BS glasses with high-CFS cations for enhancing the radiation resistance for nuclear waste storage.