An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme

Chen, Yang; Zhou, Di; Meng, Zheyi; Zhai, Jin

doi:10.1039/c6cc03943j

Cited by 27 publications

(18 citation statements)

References 19 publications

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“…In addition to the above monovalent cations responsive artificial nanochannels, several bivalent and multivalent cations responsive biomimetic nanochannels have also been constructed successfully . Our group demonstrated a copper‐responsive nanochannel system with controllable ion transport properties by immobilizing a Cu 2+ ‐responsive self‐cleaving DNAzyme into PET conical multi‐nanochannels (Fig.…”

Section: Single Responsive Biomimetic Smart Nanochannelsmentioning

confidence: 99%

“…Our group demonstrated a copper‐responsive nanochannel system with controllable ion transport properties by immobilizing a Cu 2+ ‐responsive self‐cleaving DNAzyme into PET conical multi‐nanochannels (Fig. B) . The nanochannel composite system (DNCS) can respond to Cu 2+ sensitively at a wide concentration range based on a specific DNA self‐cleaving mechanism.…”

Section: Single Responsive Biomimetic Smart Nanochannelsmentioning

confidence: 99%

“…One of the most important applications of biomimetic stimuli‐responsive nanochannels is for biochemical sensing, which can be summarized as two major approaches, one is functionalizing various recognition molecules for different analyte onto the inner wall of a nanochannel and the other is decorating recognition sites in nanochannels to recognize biomolecules. For instance, functionalized nanochannel could detect many biological and chemical species by measuring ion transport properties, including various molecules such as lactoferrin , silicatein , DNA , glucose , ATP , H 2 O 2 , amino acid , gas , and various ions such as Ag + , Cu 2+ , Hg 2+ , Zn 2+ , Pb 2+ , Fe 3+ , F − and CO 3 2− . Most recently, our group reported a cerium ions detection device by introducing the calcein onto the PET conical nanochannel .…”

Section: Applications Of Biomimetic Stimuli‐responsive Nanochannelsmentioning

confidence: 99%

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Biomimetic stimuli‐responsive nanochannels and their applications

Zhai

2019

Electrophoresis

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Biomimetic smart nanochannels have been studied extensively to achieve the precise ionic transport compared to biological ion channels. Similar to ion channels in living organisms, biomimetic smart nanochannels can respond to various stimuli, which allows for promising applications in many fields. In this review, we mainly summarize the recent advances in the design of biomimetic stimuli‐responsive nanochannels and their potential applications including biosensors and drug delivery. Finally, an outlook on the challenges and opportunities for biomimetic stimuli‐responsive nanochannels is provided.

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Section: Single Responsive Biomimetic Smart Nanochannelsmentioning

confidence: 99%

Section: Single Responsive Biomimetic Smart Nanochannelsmentioning

confidence: 99%

Section: Applications Of Biomimetic Stimuli‐responsive Nanochannelsmentioning

confidence: 99%

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Biomimetic stimuli‐responsive nanochannels and their applications

Zhai

2019

Electrophoresis

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“…Zhai and co‐workers introduced a highly specific Cu 2+ ‐induced self‐cleaving DNAzyme into conical multipore track‐etched PET membranes to create a copper‐responsive nanofluidic system . The selected DNAzyme (DNA(1)) displays a significant site‐specific cleavage only when Cu 2+ is present in the range from 10 × 10 −9 to 1 × 10 −3 m , which a nonlinear response to copper concentration.…”

Section: Rational Integration Of (Bio)molecular Architectures Into Namentioning

confidence: 99%

“…Initially the system shows high conductance due to negative charges; in the presence of Cu 2+ , DNA(1) cleaves specific sites and the negative charge density decreases (lower cation‐driven conductance). a,b) Reproduced with permission . Copyright 2016, Royal Society of Chemistry.…”

Section: Rational Integration Of (Bio)molecular Architectures Into Namentioning

confidence: 99%

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

et al. 2019

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Solid‐state nanopores are fascinating objects that enable the development of specific and efficient chemical and biological sensors, as well as the investigation of the physicochemical principles ruling the behavior of biological channels. The great variety of biological nanopores that nature provides regulates not only the most critical processes in the human body, including neuronal communication and sensory perception, but also the most important bioenergetic process on earth: photosynthesis. This makes them an exhaustless source of inspiration toward the development of more efficient, selective, and sophisticated nanopore‐based nanofluidic devices. The key point responsible for the vibrant and exciting advance of solid nanopore research in the last decade has been the simultaneous combination of advanced fabrication nanotechnologies to tailor the size, geometry, and application of novel and creative approaches to confer the nanopore surface specific functionalities and responsiveness. Here, the state of the art is described in the following critical areas: i) theory, ii) nanofabrication techniques, iii) (bio)chemical functionalization, iv) construction of nanofluidic actuators, v) nanopore (bio)sensors, and vi) commercial aspects. The plethora of potential applications once envisioned for solid‐state nanochannels is progressively and quickly materializing into new technologies that hold promise to revolutionize the everyday life.

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Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

Wang

Willner

et al. 2018

Angewandte Chemie

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Nanochannels based on smart DNA hydrogels as stimulus‐responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three‐dimensional networks with space negative charges, the ion flux and rectification ratio are significantly enhanced. Upon cyclic treatment with K+ ions and crown ether, the DNA hydrogel states could be reversibly switched between less stiff and stiff networks, providing the gating mechanism of the nanochannel. Based on the architecture of DNA hydrogels and pH stimulus, cation or anion transport direction could be precisely controlled and multiple gating features are achieved. Meanwhile, G‐quadruplex DNA in the hydrogels might be replaced by other stimulus‐responsive DNA molecules, peptides, or proteins, and thus this work opens a new route for improving the functionalities of nanochannel by intelligent hydrogels.

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An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme

Abstract: We developed an ion-gating nanochannel composite system by immobilizing a Cu(2+)-responsive self-cleaving DNAzyme into PET conical multinanochannels, which could control the ion transport by regulating the surface charge density of the channels.

Cited by 27 publications

References 19 publications

Biomimetic stimuli‐responsive nanochannels and their applications

Biomimetic stimuli‐responsive nanochannels and their applications

Molecular Design of Solid‐State Nanopores: Fundamental Concepts and Applications

Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

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