An iRGD peptide conjugated heparin nanocarrier for gastric cancer therapy

Abstract

A nontoxic, low immunogenic and high specific drug delivery system for gastric cancer.

Tumor‐Targeting W18O49 Nanoparticles for Dual‐Modality Imaging and Guided Heat‐Shock‐Response‐Inhibited Photothermal Therapy in Gastric Cancer

“…According to our previous reports, MKN‐45P cells expressed high level of integrin α v β 3 receptor while the normal gastric epithelial cells GES‐1 performed low expression of α v β 3 receptor . To identify the selective uptake of iRGD‐ W 18 O 49 ‐17AAG in gastric cancer cells, nanoparticles were modified with Cy5.5 and GES‐1 cells were used as the control group.…”

“…According to our previous reports, MKN-45P cells expressed high level of integrin α v β 3 receptor while the normal gastric epithelial cells GES-1 performed low expression of α v β 3 receptor. [23] To identify the selective uptake of iRGD-W 18 O 49 -17AAG in gastric cancer cells, nanoparticles were modified with Cy5.5 and GES-1 cells were used as the control group. As shown in Figure 4A,B, after culturing with iRGD-W 18 O 49 -17AAG, significant fluorescence signal can be observed in MKN-45P cells, while only a spot of fluorescence signal was detected in GES-1 cells.…”

“…Unfortunately, many antineoplastic agents suffered from the low penetration of only 3–5 cell diameters into cancer cells and thus resulted in poor curative effects and drug resistance in solid tumors . A recent identified tumor‐specific homing peptide with an N‐end cysteine, iRGD (CRGDK/RGPD/EC) can settle these problems simultaneously . First, iRGD could bind to integrin α v β 3 receptor which was specifically overexpressed on the tumor new vessels endothelium.…”

“…[21,22] A recent identified tumor-specific homing peptide with an N-end cysteine, iRGD (CRGDK/RGPD/EC) can settle these problems simultaneously. [23] First, iRGD could bind to integrin α v β 3 receptor which was specifically overexpressed on the tumor new vessels endothelium. iRGD was then decomposed proteolytically by Photothermal therapy (PTT) is an emerging noninvasive and precise localized therapeutic modality; however, it is deeply limited by its poor tumor accumulation, inadequate photothermal conversion efficiency, and the thermoresistance of cancer cells.…”

Carbohydrate‐based nanomaterials for biomedical applications

“…An iRGD‐heparin nanocarrier was synthesized by coupling the heparin backbone with N‐end cysteine peptide tumor‐homing peptide iRGD. The system can be used as carrier for cis‐diamminedichloroplatinum (II) delivery (Ai et al, ). A similar heparin‐based drug delivery system was prepared by heparin‐cis aconitic anhydride ligation.…”