With the development of calculation theory and bridge construction technology, single tower space main cable self-anchored suspension bridge is more and more applied to engineering practice. The purpose of this study is to calculate the main cable shape of self-anchored suspension bridge and analyze its construction process. In this study, the structural model is established firstly, and the plane model of self-anchored suspension bridge is established by using finite element software. The tension scheme of the sling is determined by analyzing the construction stage. Then the main cable alignment is calculated. The initial finished state alignment and internal force of the sling are calculated by nonlinear finite element method. The unstressed length of each cable segment is calculated according to the number of cable segments Value to analyze the results and adjust the model. The results show that the maximum deviation of the main cable alignment is 15mm; the maximum deviation of the sling force is 3%; the non-stress length deviation of the main cable is 4cm, which is 0.8% of the unstressed length of the main cable; the maximum deviation of the unstressed cable length of the sling is 11mm. It is concluded that there is not a simple linear relationship between the displacement of the main cable and the axial force of the main cable. The calculation method of the main cable shape of suspension bridge in this study can ensure that the main cable is formed into the bridge shape, at the same time, the line shape of stiffening beam is smooth, and the engineering acceptance is ensured. It makes contribution to the construction of self-anchored suspension bridge.