An MG53-IRS1-interaction disruptor ameliorates insulin resistance

Park, Jun Sub; Lee, Hyun; Choi, Bo Woon; Ro, Seonggu; Lee, Doyoung; Na, Jeong Eun; Hong, Jeoung Ho; Lee, Jae Seon; Kim, Bong Woo; Ko, Young Gyu

doi:10.1038/s12276-018-0099-9

Cited by 10 publications

(7 citation statements)

References 44 publications

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“…e purpose of Park et al is to enable anyone to semiautomatically segment anatomical structures in MRI, CT, and other medical images on a personal computer. When performing semiautomatic segmentation in Adobe Photoshop, appropriate algorithms can be used, the degree of automation can be adjusted, a convenient user interface can be used, and software errors rarely occur [1]. Bailey's team aimed to compare the relationship between stride length (SL), stride frequency (SF), and speed when running on a treadmill and on the ground.…”

Section: Introductionmentioning

confidence: 99%

Application of Low-Intensity Laser in the Treatment of Skeletal Muscle Injury in Runners

Chen

2022

Emergency Medicine International

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With the continuous improvement of people’s economic level, running, as the most common sports, is not limited by sports venues and sports levels and deeply loved by people. However, during running, soft tissue resonates with the impact force, increasing the load on joints and tendons and potentially leading to sports injuries. The purpose of this article is to study the application of low-intensity laser in the treatment of muscle strain. This article analyzes running, muscle adjustment, and lower limb stiffness. On the basis of theory, 20 healthy male college students were selected as research objects in the experimental part. The subjects were allowed to run at three speeds: slow, medium, and fast. The kinematics, dynamics, and surface EMG signals of the subjects during running were collected to analyze the effect of low-intensity laser therapy on exercise muscle strain. The experimental results showed that a low-intensity laser can effectively alleviate muscle inflammation, reduce the number of cell damage, bring the mean and integral optical density of protein to the normal level significantly, and reduce the strain degree of exercise muscle. In this article, a statistical method was used to obtain the gait cycle time (P & LT; 0.01) and support cycle time (slow P < 0.01 ).

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Section: Introductionmentioning

confidence: 99%

Application of Low-Intensity Laser in the Treatment of Skeletal Muscle Injury in Runners

Chen

2022

Emergency Medicine International

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“…Some of the genes such as ETS1 and FGFR1 have been reported to participate in the development of PCOS ( Song et al, 2019 ; Patil et al, 2020 ). Among the other genes, KLF5 is an important transcription factor that regulates androgen-AR signaling ( Li et al, 2020 ); CYP1B1, a dioxin-inducible oxidoreductase, is involved in the metabolism of estradiol ( Muneeb et al, 2014 ); IRS1 is an insulin receptor substrate gene that mediates the control of various cellular processes by insulin ( Kasch et al, 2018 ; Park et al, 2018 ). These genes were significantly enriched in biological processes of adipocyte differentiation, insulin resistance, female pregnancy, and circadian rhythm, indicating they are likely to be involved in pathogenesis of PCOS.…”

Section: Resultsmentioning

confidence: 99%

Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome

Cao

Yang

Wang

et al. 2021

Front. Cell Dev. Biol.

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Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine and metabolic disorder in women, which is characterized by androgen excess, ovulation dysfunction, and polycystic ovary. Although the etiology of PCOS is largely unknown, many studies suggest that aberrant DNA methylation is an important contributing factor for its pathological changes. In this study, we investigated DNA methylation characteristics and their impact on gene expression in granulosa cells obtained from PCOS patients. Transcriptome analysis found that differentially expressed genes were mainly enriched in pathways of insulin resistance, fat cell differentiation, and steroid metabolism in PCOS. Overall DNA methylation level in granulosa cells was reduced in PCOS, and the first introns were found to be the major genomic regions that were hypomethylated in PCOS. Integrated analysis of transcriptome, DNA methylation, and miRNAs in ovarian granulosa cells revealed a DNA methylation and miRNA coregulated network and identified key candidate genes for pathogenesis of PCOS, including BMP4, ETS1, and IRS1. Our study shed more light on epigenetic mechanism of PCOS and provided valuable reference for its diagnosis and treatment.

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“…For both breast cancer and AD there has been a drive for the identification of biomarkers for early detection, ultimately to improve long-term survival. Notably, pre-clinical studies have identified IRS-1, p53, PIN1 and LRP1 as individual potential therapeutic targets (126)(127)(128)(129)(130)(131)(132)(133) for both disease states, and changes in these are in themselves putative biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues?

et al. 2020

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This minireview is a brief overview examining the roles of insulin-like growth factors (IGFs) and the PI3K/Akt pathway in two apparently unconnected diseases: Alzheimer's dementia and cancer. For both, increased age is a major risk factor, and, in accord with the global rise in average life expectancy, their prevalence is also increasing. Cancer, however, involves excessive cell proliferation and metastasis, whereas Alzheimer's disease (AD) involves cell death and tissue destruction. The apparent "inverse" nature of these disease states is examined here, but also some important commonalities in terms of the PI3K/Akt pathway, glucose utilization and cell deregulation/death. The focus here is on four key molecules associated with this pathway; notably, the insulin receptor substrate 1 (IRS-1), cellular tumor antigen p53 (p53), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) and low-density lipoprotein receptor-related protein-1 (LRP1), all previously identified as potential therapeutic targets for both diseases. The insulin-resistant state, commonly reported in AD brain, results in neuronal glucose deprivation, due to a dampening down of the PI3K/Akt pathway, including overactivity of the mammalian target of rapamycin 1 (mTORC1) complex, hyperphosphorylation of p53 and neuronal death. This contrasts with cancer, where there is overstimulation of the PI3K/Akt pathway and the suppression of mTORC1 and p53, enabling abundant energy and unrestrained cell proliferation. Although these disease states appear to be diametrically opposed, the same key molecules are controlling pathology and, with differential targeting of therapeutics, may yet provide a beneficial outcome for both.

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An MG53-IRS1-interaction disruptor ameliorates insulin resistance

Cited by 10 publications

References 44 publications

Application of Low-Intensity Laser in the Treatment of Skeletal Muscle Injury in Runners

Application of Low-Intensity Laser in the Treatment of Skeletal Muscle Injury in Runners

Characterization of DNA Methylation and Screening of Epigenetic Markers in Polycystic Ovary Syndrome

Mini Review: Opposing Pathologies in Cancer and Alzheimer's Disease: Does the PI3K/Akt Pathway Provide Clues?

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