In this paper, the integrated scheduling of handling equipment at the railway handling area in container terminals is studied, where rail-mounted gantry cranes, internal trucks, and reach stackers are deployed. In the course of the handling operation, loading and unloading containers are handled simultaneously. The handling process is first studied and some scheduling schemes are put forward. Based on the analysis, the problem is formulated as a mixed-integer programming model, with the objectives of minimizing the makespan and the total waiting time of all equipment. Then, to solve the problem, a genetic algorithm is employed, where the first available machine rule is applied in the selection of trucks and reach stackers. Sets of numerical experiments are conducted to verify the effect of the proposed algorithm. Based on the results of experiments, some key indicators are calculated and the effects of different equipment configuration schemes are studied.