An MRI-guided targeting dual-responsive drug delivery system for liver cancer therapy

Yao, Weihe; Liu, Chenyu; Wang, Ning; Zhou, Haibin; Chen, Hailiang; Qiao, Weihong

doi:10.1016/j.jcis.2021.06.151

Cited by 13 publications

(4 citation statements)

References 43 publications

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“…Treatment with GNSPLD + UV showed a better anticancer effect and fewer side effects in vivo. (Figure 1) [72]. Yan et al used polyethylene glycol-based polymers (α-lipoic acid) and the mPEG-α-PLA copolymer to construct a double-reduction/pH response nanocarrier for capsaicin (CAP) and doxorubicin (DOX) [73].…”

Section: Research Progress On Dual-drug-delivery Nano-theranostic Age...mentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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Liver cancer has high incidence and mortality rates and its treatment generally requires the use of a combination treatment strategy. Therefore, the early detection and diagnosis of liver cancer is crucial to achieving the best treatment effect. In addition, it is imperative to explore multimodal combination therapy for liver cancer treatment and the synergistic effect of two liver cancer treatment drugs while preventing drug resistance and drug side effects to maximize the achievable therapeutic effect. Gold nanoparticles are used widely in applications related to optical imaging, CT imaging, MRI imaging, biomarkers, targeted drug therapy, etc., and serve as an advanced platform for integrated application in the nano-diagnosis and treatment of diseases. Dual-drug-delivery nano-diagnostic and therapeutic agents have drawn great interest in current times. Therefore, the present report aims to review the effectiveness of dual-drug-delivery nano-diagnostic and therapeutic agents in the field of anti-tumor therapy from the particular perspective of liver cancer diagnosis and treatment.

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Section: Research Progress On Dual-drug-delivery Nano-theranostic Age...mentioning

confidence: 99%

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Han,

Du,

Zhu

et al. 2023

Molecules

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“…For example, they have a high loading level and a long time in circulation, changing drug pharmacokinetics compared to the drug administered alone. Liposomes as carriers are safe, biodegradable, and biocompatible, making them beneficial to theragnostic (Sonali et al, 2016) (Alwattar et al, 2021) even with imaging purposes when these are conjugated with quantum dots or gold nanoclusters (Liao et al, 2021;Yao et al, 2021).…”

Section: Nanoparticles Based On Liposomes As the Carrier In Drug Deli...mentioning

confidence: 99%

Chemical Conjugation in Drug Delivery Systems

Eras

Castillo²,

Suárez³

et al. 2022

Front. Chem.

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Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer are usually so intense and invasive that they weaken the patient to cure as dangerous as the own disease. From some time ago until today, to reduce resistance generated by the constant administration of the drug and improve its pharmacokinetics, scientists have been developing drug delivery system (DDS) technology. DDS platforms aim to maximize the drugs’ effectiveness by directing them to reach the affected area by the disease and, therefore, reduce the potential side effects. Erythrocytes, antibodies, and nanoparticles have been used as carriers. Eleven antibody–drug conjugates (ADCs) involving covalent linkage has been commercialized as a promising cancer treatment in the last years. This review describes the general features and applications of DDS focused on the covalent conjugation system that binds the antibody carrier to the cytotoxic drug.

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“…Various multiresponsive drug delivery systems have been developed combining both passive and active release stimuli into one carrier with light-responsive moieties serving a major role to enhance drug delivery capabilities. 54,55 Finally, while tissue penetration and damage have typically been disadvantages of light-responsive liposomes, the development of near-IR-mediated release using porphyrin−lipid conjugates has aided in alleviating these issues. 56−59 Cargo release from porphyrin−lipid containing liposomes involves transient pore formation within the membrane resulting from photooxidation of unsaturated lipids.…”

Section: Demolition: Triggered Release Of Encapsulated Cargo From Lip...mentioning

confidence: 99%

“…Liposomes of ∼120 nm diameters were formed, and maximum release was achieved within 30 min under pH 5. Various multiresponsive drug delivery systems have been developed combining both passive and active release stimuli into one carrier with light-responsive moieties serving a major role to enhance drug delivery capabilities. , …”

Section: Demolition: Triggered Release Of Encapsulated Cargo From Lip...mentioning

confidence: 99%

Demolish and Rebuild: Controlling Lipid Self-Assembly toward Triggered Release and Artificial Cells

et al. 2021

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The ability to modulate the structures of lipid membranes, predicated on our nuanced understanding of the properties that drive and alter lipid self-assembly, has opened up many exciting biological applications. In this Perspective, we focus on two endeavors in which the same principles are invoked to achieve completely opposite results. On one hand, controlled liposome decomposition enables triggered release of encapsulated cargo through the development of synthetic lipid switches that perturb lipid packing in the presence of disease-associated stimuli. In particular, recent approaches have utilized artificial lipid switches designed to undergo major conformational changes in response to a range of target conditions. On the other end of the spectrum, the ability to drive the in situ formation of lipid bilayer membranes from soluble precursors is an important component in the establishment of artificial cells. This work has culminated in chemoenzymatic strategies that enable lipid manufacturing from simple components. Herein, we describe recent advancements in these two unique undertakings that are linked by their reliance on common principles of lipid self-assembly.

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An MRI-guided targeting dual-responsive drug delivery system for liver cancer therapy

Cited by 13 publications

References 43 publications

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Review of the Application of Dual Drug Delivery Nanotheranostic Agents in the Diagnosis and Treatment of Liver Cancer

Chemical Conjugation in Drug Delivery Systems

Demolish and Rebuild: Controlling Lipid Self-Assembly toward Triggered Release and Artificial Cells

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