An Obese Body Mass Increases the Adverse Effects of HIV/AIDS on Balance and Gait

Bauer, Lance O.; Wu, Zhan; Wolfson, Leslie

doi:10.2522/ptj.20100292

Cited by 41 publications

(53 citation statements)

References 34 publications

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“…However, we did not find differences in objective testing of vestibular function between the HIV-infected and HIV-uninfected men and women in this same cohort [18], and found no association between falls and symptoms of vertigo in the current analysis. Prior studies have shown impairments in objective measures of imbalance in approximately 10% of middle-aged HIV-infected persons on effective ART [11,41], with HIVinfected persons demonstrating poorer performance on objective laboratory or clinically based imbalance measures compared with HIV-uninfected controls [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Fall frequency and associated factors among men and women with or at risk for HIV infection

et al. 2016

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Background Falls and fall-related injuries are a major public health concern. HIV-infected adults have been shown to have a high incidence of falls. Identification of major risk factors for falls that are unique to HIV or similar to the general population will inform development of future interventions for fall prevention. Methods HIV-infected and uninfected men and women participating in a Hearing and Balance Sub-study of the Multicenter AIDS Cohort Study and Women’s Interagency HIV Study were asked about balance symptoms and falls during the prior 12 months. Falls were categorized as 0, 1, or ≥ 2; proportional odds logistic regression models were used to investigate relationships between falls and demographic and clinical variables and multivariable models were created. Results 24% of 303 HIV-infected participants reported ≥1 fall compared to 18% of 233 HIV-uninfected participants (p=0.27). HIV-infected participants were demographically different from HIV-uninfected participants, and were more likely to report clinical imbalance symptoms (p≤0.035). In univariate analyses, more falls were associated with hepatitis C, female sex, obesity, smoking, and clinical imbalance symptoms, but not age, HIV serostatus, or other comorbidities. In multivariable analyses, female sex and imbalance symptoms were independently associated with more falls. Among HIV-infected participants, smoking, number of medications, and imbalance symptoms remained independent fall predictors while current protease inhibitor use was protective. Discussion Similar rates of falls among HIV-infected and uninfected participants were largely explained by a high prevalence of imbalance symptoms. Routine assessment of falls and dizziness/imbalance symptoms should be considered, with interventions targeted at reducing symptomatology.

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Section: Discussionmentioning

confidence: 99%

Fall frequency and associated factors among men and women with or at risk for HIV infection

et al. 2016

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“…Obesity and the metabolic syndrome are established risk factors for the development of physical function impairment or frailty among middle-aged or older HIV-infected adults[90–93]. Obesity has also been associated with fall risk in HIV-infected women[94].…”

Section: Consequences Of Obesity and Visceral Adipositymentioning

confidence: 99%

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

Lake

2017

Curr HIV/AIDS Rep

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Purpose of Review To summarize knowledge of the prevalence, relevant physiology and consequences of obesity and visceral adiposity in HIV-infected adults, including highlighting gaps in current knowledge and future research directions. Recent Findings Similar to the general population, obesity prevalence is increasing among HIV-infected persons, and obesity and visceral adiposity are associated with numerous metabolic and inflammatory sequelae. However, HIV- and antiretroviral therapy (ART)-specific factors may contribute to fat gain and fat quality in treated HIV infection, particularly to the development of visceral adiposity, and sex differences may exist. Summary Obesity and visceral adiposity commonly occur in HIV-infected persons and have significant implications for morbidity and mortality. Future research should aim to better elucidate the HIV- and ART-specific contributors to obesity and visceral adiposity in treated HIV infection, with the goal of developing targeted therapies for the prevention and treatment of obesity and visceral adiposity in the modern ART era.

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“…Obesity and the metabolic syndrome are well-established risk factors for the development of physical function impairment or frailty among geriatric HIV-uninfected populations [18] and middle-aged or older HIV-infected adults [19-21]. Similarly, obesity is a known risk factor for diabetes mellitus and cardiovascular disease (CVD), and increased CVD risk has been described among obese and lipohypertrophic, HIV-infected adults [22].…”

Section: Discussionmentioning

confidence: 99%

Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

Erlandson

Lake

2016

Curr HIV/AIDS Rep

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More than one-third of adults in the United States are obese, and obesity-related disease accounts for some of the leading causes of preventable death. Mid-life obesity may be a strong predictor of physical function impairment later in life regardless of body mass index (BMI) in older age, highlighting the benefits of obesity prevention on health throughout the lifespan. Adipose tissue disturbances including lipodystrophy and obesity are prevalent in the setting of treated and untreated HIV infection. This article will review current knowledge on fat disturbances in HIV-infected persons, including therapeutic options and future directions.

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An Obese Body Mass Increases the Adverse Effects of HIV/AIDS on Balance and Gait

Abstract: The present findings have an obvious and unfortunate implication: as more patients who are HIV-1 seropositive join the seronegative community in becoming obese, the effects of obesity and their disease may summate and their risk for balance and gait problems may increase.

Cited by 41 publications

References 34 publications

Fall frequency and associated factors among men and women with or at risk for HIV infection

Fall frequency and associated factors among men and women with or at risk for HIV infection

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

Fat Matters: Understanding the Role of Adipose Tissue in Health in HIV Infection

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