An objective marker of lactate-induced panic

Gorman, Jack M.; Davies, Marc; Steinman, Richard C.; Liebowitz, Michael R.; Fyer, Abby J.; Coromilas, James; Klein, Donald F.

doi:10.1016/0165-1781(87)90113-2

Cited by 21 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alternatively, asthmatic patients may not be able to manage a better motor response to the challenge of balancing on a mobile platform because of their postural alterations of chest, shoulder, and spine. Finally, a third possibility is that asthmatic individuals have a CO 2 chemoreceptor hypersensitivity similar to that described for panic disorder patients (31,32). According to this hypothesis, anxiety and postural instability could be induced by the same respiratory mechanism.…”

Section: Discussionmentioning

confidence: 93%

Balance Disturbances in Asthmatic Patients

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 93%

Balance Disturbances in Asthmatic Patients

et al. 2012

View full text Add to dashboard Cite

show abstract

“…In man spontaneous and lactate-induced panic are often, but not always, accompanied by an increase in blood pressure as well as in heart rate (Gaffney et al 1988;Gorman et al 1987Gorman et al , 1990Yeragani et al 1989); in contrast, most studies addressing the role of sympathetic activity in lactate-induced panic have failed to show a clear increase in plasma catecholamines after lactate administration (Liebowitz et al 1985). Moreover, the heart rate response to lactate cannot be antagonized by a beta-receptor antagonist (Gorman et al 1984).…”

Section: Discussionmentioning

confidence: 99%

Sodium Lactate Elicits a Rapid Increase in Blood Pressure in Wistar Rats and Spontaneously Hypertensive Rats Effect of Pretreatment with the Antipanic Drugs Clomipramine and Alprazolam

Wikander

Roos

Stakkestad

et al. 1995

Neuropsychopharmacology

View full text Add to dashboard Cite

Intravenous administration of sodium lactate in concentrations (0.5 M, 2 M) previously shown to elicit panic attacks in patients with panic disorder was found to cause a prompt and short-lasting increase in blood pressure in spontaneously hypertensive (SH) rats and in normotensive Wistar rats; in contrast, only weak and nonsignificant effects of lactate were observed in rats of the Sprague-Dawley strain. The effects of lactate on heart rate in SH rats varied; thus, whereas most rats displayed a modest bradycardia during lactate infusions, in some rats the increase in blood pressure was accompanied by an increase in heart rate. After pretreatment with antipanic medication [the serotonin and noradrenaline reuptake inhibitor clomipramine (10 mg/kg/day, 3 weeks) or the triazolobenzodiazepine alprazolam (2 mg/kg/day, 3 weeks)], the blood pressure response to sodium lactate in SH rats was significantly blunted; in contrast, acute pretreatment with clomipramine (10 mg/kg) did not reduce the response. It is suggested that further studies on the cardiovascular effects of sodium lactate in SH or Wistar rats may shed further light on the mechanisms underlying the panic-provoking effect of lactate in panic disorder patients and on the mode of action of antipanic drugs.

show abstract

“…Despite this definition, Barlow, Brown, and Craske (1994) noted inconsistencies across studies in the way panic is defined, and concern that true panic is confounded with anticipatory anxiety, partly because of the lack of objective indices for panic. Attempts to quantify panic by sudden surges of heart rate (e.g., Gorman et al, 1987; Taylor et al, 1986) have difficulty accounting for the report of panic in the absence of heart rate elevations (e.g., Taylor et al, 1986). On the other hand, more severe self‐reports of panic were more likely to be accompanied by heart rate elevations (Taylor et al, 1986), suggesting that panics without heart rate elevation may have reflected mild panic or anticipatory anxiety.…”

Section: Research Issues and Obstaclesmentioning

confidence: 99%

Nocturnal panic.

Craske¹,

Rowe²

1997

Clinical Psychology: Science and Practice

View full text Add to dashboard Cite

This article reviews the phenomenon of nocturnal panic, or waking from sleep in a state of panic. The review covers the presenting hatures of nocturnal panic and the evidence for cognitive and physiological mediating variables. A psychobiological conceptualization that parallels conceptualirations for daytime panic attacks is offered. Obstacles for future research in this ana include ambiguities in the definition of nocturnal panic, and Its distinctiveness from other sleep disorders, as well as measurement issues. Implications from a psychobiological conceptualization include the appropriateness of cognitive-behavioral treatment for nocturnal panic.

show abstract

An objective marker of lactate-induced panic

Cited by 21 publications

References 16 publications

Balance Disturbances in Asthmatic Patients

Balance Disturbances in Asthmatic Patients

Sodium Lactate Elicits a Rapid Increase in Blood Pressure in Wistar Rats and Spontaneously Hypertensive Rats Effect of Pretreatment with the Antipanic Drugs Clomipramine and Alprazolam

Nocturnal panic.

Contact Info

Product

Resources

About