An Observation of the Role of Autophagy in Patients with Endometriosis of Different Stages during Secretory Phase and Proliferative Phase

Li, Meng; Lu, Meisong; Liu, Meiling; Deng, Suo; Tang, Xiao‐Han; Han, Cui; Wang, Hongli; Li, Peiling

doi:10.2174/1566523218666181008155039

Cited by 9 publications

(4 citation statements)

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“…Autophagy, another form of programmed cell death, involves a series of catabolic processes that depend on the lysosomal degradation of proteins and cytoplasmic organelles, which are closely related to cellular proliferation and apoptosis ( Popli et al, 2022 ). The expression levels of autophagy-related genes such as microtubule-associated protein light chain 3 (LC3) and Beclin-1 have been shown to be reduced in the serum, PF, and eutopic endometrial tissue of patients with EMs compared with the levels in healthy controls ( Sui et al, 2018 ), and the level of expression of autophagy-related genes (LC3B-II) was significantly reduced in ectopic endometrium compared with that in the eutopic endometrial tissues of patients with EMs ( Li et al, 2018 ). Inhibition of autophagy can promote the expression of inflammatory cytokines, trigger inflammation and immune responses leading to autoimmune damage, enable endometrial cells to evade immune surveillance, and ultimately promote ectopic growth and implantation of ectopic endometrial cells in the peritoneal cavity ( Ji et al, 2022 ).…”

Section: Possible Associations Of Adiponectin With the Pathogenesis O...mentioning

confidence: 99%

The mysterious association between adiponectin and endometriosis

Zhao,

Ren,

et al. 2024

Front. Pharmacol.

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Adiponectin is a pleiotropic cytokine predominantly derived from adipose tissue. In addition to its role in regulating energy metabolism, adiponectin may also be related to estrogen-dependent diseases, and many studies have confirmed its involvement in mediating diverse biological processes, including apoptosis, autophagy, inflammation, angiogenesis, and fibrosis, all of which are related to the pathogenesis of endometriosis. Although many researchers have reported low levels of adiponectin in patients with endometriosis and suggested that it may serve as a protective factor against the development of the disease. Therefore, the purpose of this review was to provide an up-to-date summary of the roles of adiponectin and its downstream cytokines and signaling pathways in the aforementioned biological processes. Further systematic studies on the molecular and cellular mechanisms of action of adiponectin may provide novel insights into the pathophysiology of endometriosis as well as potential therapeutic targets.

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Section: Possible Associations Of Adiponectin With the Pathogenesis O...mentioning

confidence: 99%

The mysterious association between adiponectin and endometriosis

Zhao,

Ren,

et al. 2024

Front. Pharmacol.

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“…The change of autophagy can also affect the occurrence of tumor [ 76 ]. Astragaloside IV ( AS-IV ) regulated the expression of p53, activated the Ambra1/Beclin1 complex in gastric precancerous lesions (GPL), decreased gastric mucosal injury, and prevented gastric mucosal atrophy, intestinal metaplasia, and atypical hyperplasia.…”

Section: Autophagymentioning

confidence: 99%

Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target

Guo

Chai

et al. 2021

BioMed Research International

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The incidence of stomach diseases is very high, which has a significant impact on human health. Damaged gastric mucosa is more vulnerable to injury, leading to bleeding and perforation, which eventually aggravates the primary disease. Therefore, the protection of gastric mucosa is crucial. However, existing drugs that protect gastric mucosa can cause nonnegligible side effects, such as hepatic inflammation, nephritis, hypoacidity, impotence, osteoporotic bone fracture, and hypergastrinemia. Autophagy, as a major intracellular lysosome-dependent degradation process, plays a key role in maintaining intracellular homeostasis and resisting environmental pressure, which may be a potential therapeutic target for protecting gastric mucosa. Recent studies have demonstrated that autophagy played a dual role when gastric mucosa exposed to biological and chemical factors. More indepth studies are needed on the protective effect of autophagy in gastric mucosa. In this review, we focus on the mechanisms and the dual role of various biological and chemical factors regulating autophagy, such as Helicobacter pylori, virus, and nonsteroidal anti-inflammatory drugs. And we summarize the pathophysiological properties and pharmacological strategies for the protection of gastric mucosa through autophagy.

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“…Recently, the role of autophagy has been emphasized on the progress of EMS [21]. The autophagy level of eESCs is downregulated, which further promotes the survival and inhibits the apoptosis of eESCs [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression

Lin

et al. 2022

Preprint

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Background: Endometriosis (EMS), an estrogen-dependent disease, is characterized by dysregulated inflammation and increased estrogen in ectopic lesions. However, the crosstalk and pathogenic mechanism of inflammation and estrogen has not been fully explored. SCM-198 is the synthetic form of leonurine with multiple pharmacological activities. Whether SCM-198 could inhibit the progress of EMS by regulating inflammation and estrogen signaling remains unknown. Methods: The therapeutic effects and potential mechanisms of SCM-198 on EMS were analyzed by establishing EMS mice models and performing RNA-seq assay. ELISA was performed to detect estrogen and TNF-α concentration in normal endometrial stromal cells (nESCs) and ectopic endometrial stromal cells (eESCs), with or without SCM-198 treatment. Western blotting, RNA silencing and plasmid overexpression were utilized to analyze the relationship among inflammation, endocrine and autophagy as well as the regulation of SCM-198 on inflammation-endocrine-autophagy axis. Results: Increased estrogen-ERα signaling and decreased PR expression co-led to the hypo-autophagy state in eESCs, which further inhibited the apoptosis of eESCs. Highly expressed TNF-α in eESCs enhanced low-autophagy mediated anti-apoptosis effect by activating aromatase-estrogen-ERα signaling. SCM-198 inhibited the growth of ectopic lesions in EMS mouse model and promoted the apoptosis of eESCs both in vivo and in vitro. The apoptosis effect of SCM-198 on eESCs were realized by upregulating the autophagy level via inhibiting TNF-α activated aromatase-estrogen-ERα signaling and increasing PR expression. Conclusion: Inflammation facilitated the progress of EMS by disturbing estrogen regulatory axis. SCM-198 restrained the growth of EMS by regulating inflammation-endocrine-autophagy axis.

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An Observation of the Role of Autophagy in Patients with Endometriosis of Different Stages during Secretory Phase and Proliferative Phase

Cited by 9 publications

References 0 publications

The mysterious association between adiponectin and endometriosis

The mysterious association between adiponectin and endometriosis

Autophagy in Gastric Mucosa: The Dual Role and Potential Therapeutic Target

SCM-198 Prevents Endometriosis By Reversing Low Autophagy Levels Of Endometriotic Stromal Cells Via Inhibiting TNF-Α-Aromatase-Estrogen-Erα Pathway And Promoting PR Expression

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