An observational study investigating the effect of platelet function on outcome after colorectal surgery

Keeler, Barrie; Simpson, John; Fox, Susan C.; Stavrou, Christiana L.; Briggs, R; Patel, Priya; Heptinstall, S; Acheson, Austin G

doi:10.1016/j.ijsu.2015.02.023

Cited by 5 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aspirin test showed that P-selectin expression rose with the length of time between stopping aspirin and surgery. Although the proportion of patients with a complication, including those with hemorrhage, was higher in the aspirin group, P-selectin expression was not associated with complications or bleeding (43).…”

Section: Surgerymentioning

confidence: 73%

“…The question then arises as to whether this should be stopped temporarily before major surgery to prevent the perceived risk of increased operative blood loss. In an observational study, the effect of stopping aspirin preoperatively in 20 patients having colorectal surgery was assessed and compared with a group who were not on aspirin (43). P-selectin expression was lower on aspirin (Table I) and within 5 days of stopping aspirin prior to surgery.…”

Section: Surgerymentioning

confidence: 99%

See 1 more Smart Citation

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders

2018

View full text Add to dashboard Cite

Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing platelet function tests may not be ideal in that they can be expensive, are often time consuming, and measurements must be made near to the patient and within a few hours of blood collection. Platelet activation leads to translocation of P-selectin from alpha-granules to the cell surface. Following activation with arachidonic acid (which is blocked by aspirin) or adenosine diphosphate (inhibited by clopidogrel) and fixation, samples may be stored or posted to a laboratory performing flow cytometric quantification of platelet P-selectin expression. Acute myocardial infarction and ischemic stroke are associated with high platelet reactivity on clopidogrel in 6-58% of patients when assessed with P-selectin expression, and high reactivity was associated with an increased risk of recurrence after myocardial infarction. Use of P-selectin expression tests may also be of relevance to surgical and veterinary practice and the diagnosis of mild bleeding disorders. The present review explores this topic in further detail.

show abstract

Section: Surgerymentioning

confidence: 73%

Section: Surgerymentioning

confidence: 99%

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders

2018

View full text Add to dashboard Cite

show abstract

“…The study demonstrated the effects of antiplatelet therapy being taken on admission with acute stroke on the measurements performed as part of the TARDIS study [Bath PM et al Remote assessment of platelet function in patients with acute stroke or transient ischaemic attack, Submitted (2016)]. The approach has also been used to assess the residual effects of aspirin in surgical patients from whom this antiplatelet agent had been withdrawn [56]. The approach is also finding a use for determining the efficacy of antiplatelet agents in veterinary medicine [57].…”

Section: Methods Based On Measurements Of Platelet Activation Markersmentioning

confidence: 99%

Novel Strategies for Assessing Platelet Reactivity

Algahtani

Heptinstall

2016

Future Cardiol.

View full text Add to dashboard Cite

There are many approaches to assessing platelet reactivity and many uses for such measurements. Initially, measurements were based on the ability of platelets separated from other blood cells to aggregate together following activation with an appropriate 'aggregating agent'. Later, measurements of platelet aggregation in blood itself were performed, and this led to a point-of-care approach to platelet function testing. Measurement of secretory activity through the appearance of the activation marker Pselectin on platelets now provides an alternative approach, which enables remote testing. Measurement of vasodilator-stimulated phosphoprotein phosphorylation is also moving toward application in situations remote from the testing laboratory. Here we provide an overview of the various approaches that are now available, assess their advantages and disadvantages, and describe some of the clinical situations in which they are being used. Keywordsaspirin, flow cytometry, light transmission aggregometry (LTA), multiplate electrode aggregometry (MEA), P-selectin, P2Y12 antagonists, platelet aggregation, platelet reactivity, VASP phosphorylation, VerifyNow Platelet reactivity is a broad term indicating the degree of the response of blood platelets to an external stimulus, usually an 'aggregating agent'. Platelet reactivity can be measured in many different ways and the purpose of this review is to summarize the approaches, with an emphasis on the newer approaches that are becoming available.Platelets play an important role in the hemostatic process [1,2]. They contribute to the formation of a hemostatic plug that serves to prevent blood loss from injured blood vessels. The hemostatic plug contains thousands of platelets that have aggregated together within a network of fibrin. However, platelets also contribute to the generation of a thrombotic mass in a coronary or cerebral artery or in an artificial stent leading to blockage and resulting in conditions such as heart attack, stroke and stent thrombosis [3,4]. A thrombus is also composed of platelet aggregates within a fibrin network. So thrombus formation can thus be considered to be hemostasis in the wrong place.

show abstract

What are the risk factors of failure of enhanced recovery after right colectomy? Results of a prospective study on 140 consecutive cases

Destan

Brouquet

Carbonnières

et al. 2020

Int J Colorectal Dis

View full text Add to dashboard Cite

An observational study investigating the effect of platelet function on outcome after colorectal surgery

Cited by 5 publications

References 18 publications

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders

Clinical utility of remote platelet function measurement using P-selectin: assessment of aspirin, clopidogrel, and prasugrel and bleeding disorders

Novel Strategies for Assessing Platelet Reactivity

What are the risk factors of failure of enhanced recovery after right colectomy? Results of a prospective study on 140 consecutive cases

Contact Info

Product

Resources

About