An off-on fluorescence probe targeting mitochondria based on oxidation-reduction response for tumor cell and tissue imaging

Yao, Hanchun; Cao, Li; Zhao, Weiwei; Zhang, Suge; Zeng, Man; Du, Bin

doi:10.1007/s11051-017-4030-4

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…In conclusion, this paper introduces a novel off-on fluorescent probe called SSC-Ni for the detection of nickel (II) ion. Similar to the TaqMan probes, SSC-Ni operates on the principle of off-on fluorescence, with a lower background Frontiers in Bioengineering and Biotechnology frontiersin.org fluorescence signal (Yao et al, 2017). When exposed to nickel ions, the probe undergoes degradation, leading to the release of fluorescence signals, The rate of fluorescence signal enhancement is directly proportional to the concentration of nickel ions.…”

Section: Discussionmentioning

confidence: 99%

A novel “off-on” fluorescent probe for the detection of nickel ions and its clinical application

Yi,

Wang,

et al. 2023

Front. Bioeng. Biotechnol.

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Nickel serves as an essential micronutrient for the human body, playing a vital role in various enzymatic processes. However, excessive nickel entering the environment can cause pollution and pose serious risks to animals, plants, and human health. High concentrations of nickel ions in the human body increase the risk of various diseases, highlighting the need for accurate measurement of nickel ions levels. In this study, we designed a sequence-specific cleavage probe for nickel (II) ion called SSC-Ni. Similar to the TaqMan probe, SSC-Ni is an off-on fluorescent probe with an exceptionally low background fluorescence signal. It exhibits high detection specificity, making it highly selective for nickel ions, and the detection limit of the probe towards Ni2+ is as low as 82 nM. The SSC-Ni probe can be utilized for convenient and cost-effective high-throughput quantitative detection of nickel ions in serum. Its user-friendly operation and affordability make it a practical solution. By addressing the lack of simple and effective nickel ion detection methods, this probe has the potential to contribute significantly to environmental monitoring and the protection of human health.

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Section: Discussionmentioning

confidence: 99%

A novel “off-on” fluorescent probe for the detection of nickel ions and its clinical application

Yi,

Wang,

et al. 2023

Front. Bioeng. Biotechnol.

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show abstract

“…Li's group reported a simple fluorescent probe, which has the capability of recognizing cancer cells from normal cells. 12–14 Chang's group first devised a probe for detecting sulfite selectively by utilizing the mechanism of sulfite-selective deprotection of levylinate. 15 However, the lifetime of traditional fluorescence is usually on the order of nanosecond, which makes observations difficult.…”

Section: Introductionmentioning

confidence: 99%