1975
DOI: 10.1152/jn.1975.38.5.1269
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An olfactory projection area in orbitofrontal cortex of the monkey

Abstract: An olfactory projection area was studied in monkeys anesthetized with Nembutal. 1. Evoked potentials were recorded when the olfactory bulb (OB) was electrically stimulated in the lateroposterior portion of the orbitofrontal cortex (LPOF). However, those potentials disappeared when the anterior pyriform cortex (AP) (probably together with the medial portion of the amygdala (MA)) was aspirated or electrically destroyed. 2. In nearly the entire hypothalamic region, evoked potentials were recorded by the same stim… Show more

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Cited by 204 publications
(68 citation statements)
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“…While some neuroradiological studies have associated alcoholics" cognitive deficits with specific cortical and/or subcortical changes (1, 2, 10, 411, the present study represents the first attempt at such brain-behavior analyses of these patients' olfactory impairments. Based upon the established neuroanatomical circuits underlying olfaction (26,31,37,38), damage to the medial diencephalon, the anterior portions of the temporal lobes and/or orbitofrontal cortex would seem the most likely neurologic basis of the alcoholics' deficiencies in odor identification. Both Jones and her colleagues (20-221 and Potter and Butters (29) emphasized the role of diencephalic structures in the olfactory problems of amnesic and nonamnesic alcoholics, but demonstrations (23,30) that damage to the orbital frontal and temporal cortices result in severe deficits on the UPSIT suggest that alcoholics" impairments in odor identification may be related to cortical rather than to subcortical factors.…”
Section: Discussionmentioning
confidence: 99%
“…While some neuroradiological studies have associated alcoholics" cognitive deficits with specific cortical and/or subcortical changes (1, 2, 10, 411, the present study represents the first attempt at such brain-behavior analyses of these patients' olfactory impairments. Based upon the established neuroanatomical circuits underlying olfaction (26,31,37,38), damage to the medial diencephalon, the anterior portions of the temporal lobes and/or orbitofrontal cortex would seem the most likely neurologic basis of the alcoholics' deficiencies in odor identification. Both Jones and her colleagues (20-221 and Potter and Butters (29) emphasized the role of diencephalic structures in the olfactory problems of amnesic and nonamnesic alcoholics, but demonstrations (23,30) that damage to the orbital frontal and temporal cortices result in severe deficits on the UPSIT suggest that alcoholics" impairments in odor identification may be related to cortical rather than to subcortical factors.…”
Section: Discussionmentioning
confidence: 99%
“…The modulatory effects of attention on each of the connections was obtained by subtracting the modulatory effect of tone attention from that of odor attention and then testing the significance of these differential effects with one-sample t tests ( p Ͻ 0.05, one-tailed). To the extent that aPC, pPC, MD thalamus, and OFC are principally linked via excitatory glutamatergic pathways (Tanabe et al, 1975;Yarita et al, 1980;Carmichael et al, 1994;Haberly, 2001), the use of one-tailed t tests enabled us to specifically test the hypothesis that odor (vs tone) attention would strengthen regional coupling in the positive direction (i.e., faster or stronger connections Ͼ0), in keeping with the known basic physiology of these neural circuits. Finally, to compare modulatory effects of attentional context on the direct and indirect pathways, we computed the modulatory effect for the whole indirect pathway by averaging the modulatory effects for the three connections involved in the indirect pathway (aPC to pPC, pPC to MD thalamus, MD thalamus to OFC) and comparing this with the direct pathway (aPC to OFC).…”
Section: Effective Connectivity Analysismentioning
confidence: 99%
“…These studies suggest that odor information projects from piriform cortex (PC) to olfactory orbitofrontal cortex (OFC) by two different pathways (Tanabe et al, 1975;Yarita et al, 1980;Russchen et al, 1987;Ray and Price, 1992;Carmichael et al, 1994). The principal ("direct") pathway projects directly from PC to OFC and is considered the dominant route for olfactory transmission to neocortical brain areas.…”
Section: Introductionmentioning
confidence: 99%
“…The orbitofrontal cortex was identified as the olfactory area cortex in rhesus monkeys (Tanabe et al, 1975).…”
Section: Introductionmentioning
confidence: 99%