An on-line, column-switching high-performance liquid chromatographic procedure for the removal of probenecid from human plasma, serum, or urine in the quantitative determination of cefmetazole or cefoxitin

Bothwell, W; Cathcart, K. S.; Bombardt, Paul A.

doi:10.1016/0731-7085(89)80024-x

Cited by 11 publications

(4 citation statements)

References 3 publications

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“…Although ureteral injuries are uncommon, with a reported incidence rate between 0.007% and 1.8%,1–3 recognition of such injury is often delayed, with the average time to detection ranging from 5.3 to 180 days 4,5. Importantly, intraoperative detection of such injuries can reduce morbidity and medical costs 3,5,6.…”

Section: Introductionmentioning

confidence: 99%

Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue

Matsui

Tanaka

Choi

et al. 2010

Surgery

121

101

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Section: Introductionmentioning

confidence: 99%

Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue

Matsui

Tanaka

Choi

et al. 2010

Surgery

121

101

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“…The concentrations of cefmetazole in plasma and urine samples were determined by a minor modification of a semiautomated high-performance liquid chromatographic method (2). This method was precise and accurate to 2 ,ug of cefmetazole per ml in plasma and 15 ,ug of cefmetazole per ml in urine.…”

mentioning

confidence: 99%

Disposition of cefmetazole in healthy volunteers and patients with impaired renal function

Halstenson

Guay

Opsahl

et al. 1990

Antimicrob Agents Chemother

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The disposition of cefmetazole was studied in 25 subjects with various degrees of renal function after a 1,000-mg, constant-rate, 30-min intravenous infusion of cefmetazole sodium. In six subjects with creatinine clearance (CLCR) of >90 m/min per 1.73 m2 (group 1), the terminal elimination half-life (t4123) was 1.31 0.54 h (mean + standard deviation), cefmetazole total body clearance (CLp) was 132.8 25.1 ml/min per 1.73 m2, and volume of distribution at steady state was 0.165 ± 0.025 liter/kg. The fraction of dose excreted unchanged in the urine was 84.0% ± 26.1%. Subjects with CLcRs of 40 to 69 (group 2, n = 6) and 10 to 39 (group 3, n -6) ml/min per 1.73 m2 demonstrated prolongation of the tl12,3 (3.62 ± 1.06 and 5.93 ± 1.81 h, respectively) and significant reductions in cefmetazole CLp (52.8 ± 14.3 and 30.2 ± 10.2 ml/min per 1.73 m2, respectively), compared with group 1. In seven subjects on chronic hemodialysis (group 4) studied during an interdialytic period, the cefmetazole tl/2, was increased to 24.10 ± 8.12 h and the CLp was reduced to 6.8 ± 2.1 ml/min per 1.73 M2. Cefmetazole CLp correlated positively with CLCR (r = 0.951, P < 0.001): CLp = (1.181 CLCR) -0.287. The disposition of cefmetazole was also assessed in six group 4 subjects during an intradialytic period.The t1/2, during hemodialysis (2.09 ± 0.69 h) was significantly shorter than that observed during the interdialytic period. The hemodialysis clearance of cefmetazole was 86.1 ± 20.1 ml/min, and the fraction of cefmetazole removed during hemodialysis was 59.8% ± 5.9%. It is recommended that patients with renal insufficiency receive standard doses of cefmetazole at extended intervals and patients on maintenance hemodialysis receive standard doses after hemodialysis.Cefmetazole sodium is an investigational parenteral cephamycin antibiotic possessing activity against a broad spectrum of both gram-positive and gram-negative aerobic and anaerobic bacteria (3, 6, 11, 13). The MIC for 90% of strains of clinically important pathogens, such as Staphylococcus aureus, Escherichia coli, Klebsiella spp., Proteus mirabilis, Haemophilus influenzae, and Neisseria spp., ranges between 0.012 and 4 ,ug/ml (6). Clinical studies in humans have demonstrated efficacy in the treatment of various infections (15), including pneumonia (L.

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“…of 0.18 ng/ml were obtained. The sensitivity achieved by this method was better than the reported method for CMZ [25][26][27][28] and the HPLC-UV method used for residue monitoring in general [10][11][12][13].…”

Section: Limit Of Detection (Lod) Limit Of Quantitation (Loq) and LImentioning

confidence: 47%

“…Analytical methods for determination of CMZ in serum by HPLC with UV detection have been reported [25][26][27][28]; a sensitivity of 1.3 g/ml using a column switching technique [26] and that of 20 ng/ml with microbore HPLC [28] was achieved. However, as described above, a sensitive analytical method should be employed for monitoring of ␤-lactam antibiotic residues, and the chemiluminescence method is expected to be more sensitive than those methods.…”

Section: Introductionmentioning

confidence: 99%

Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis

Fukutsu¹,

Konse²,

Ḱawasaki³

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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An on-line, column-switching high-performance liquid chromatographic procedure for the removal of probenecid from human plasma, serum, or urine in the quantitative determination of cefmetazole or cefoxitin

Cited by 11 publications

References 3 publications

Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue

Real-time, near-infrared, fluorescence-guided identification of the ureters using methylene blue

Disposition of cefmetazole in healthy volunteers and patients with impaired renal function

Determination of cefmetazole residue at pharmaceutical manufacturing facilities by chemiluminescence flow injection analysis

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