An open-label, dose escalation pilot study of the effect of clonazepam in burning mouth syndrome

Grushka, Miriam; Epstein, Joel B.; Mott, April E.

doi:10.1016/s1079-2104(98)90345-6

Cited by 147 publications

(126 citation statements)

References 11 publications

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“…12,20 Several studies have also shown that the burning sensation often occurs in more than one oral site, with the anterior two thirds of the tongue, the anterior hard palate and the mucosa of the lower lip most frequently involved. 9,10,21 In present study the most common affected area tongue with 83% which was similar with studies conducted by Bergdahl 12 and Grushka 10 and higher than by Eguia Del Valle et al 22 reported that the tip of the tongue was the most common location (71%).…”

Section: Bergdahl and Bergdahlsupporting

confidence: 90%

Prevalence of burning mouth syndrome in adult Turkish population

Çolak¹

2011

Dicle Med J

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ÖZETAmaç: Ağız yanması sendromu (AYS) kronik bir orofasiyal ağrı olarak tanımlanır ve semptomatik olarak dilde ve dudakta veya bütün ağız boşluğu içinde yangı tarzında bir ağrıyla karakterizedir. Uluslararası çalışmalarda Ağız yanması sendromunun prevalansının %0,6 ile %15 arasında değiştiği rapor edilmektedir. Bu çalışmada Türk toplumunda AYS prevalansının belirlenmesi amaçlanmıştır.

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Section: Bergdahl and Bergdahlsupporting

confidence: 90%

Prevalence of burning mouth syndrome in adult Turkish population

Çolak¹

2011

Dicle Med J

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“…The clinical characteristics of BMS in turn suggest the possible participation of neuronal inflammation in the etiopathogenesis of the syndrome, together with a series of other mechanisms (9,10). Many treatments have been recommended for improving the symptoms of BMS, including sialogogues, topical anesthetics in rinses, anxiolytic drugs, antidepressants, anticonvulsivants, alpha-lipoic acid and psychotherapy (8,(9)(10)(11)(12)(13), though no evidence has been produced by controlled clinical trials in support of such therapies. The best results have been reported for clonazepam, administered both topically and via the systemic route, though improvement has not been documented in all cases (14,15).…”

Section: Introductionmentioning

confidence: 99%

Burning mouth syndrome: Correlation of treatment to clinical variables of the disease

Silvestre‐Rangil¹,

Silvestre²,

Tamarit-Santafé³

et al. 2011

Med Oral

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Objective: Burning mouth syndrome (BMS) is a complex disorder with a still uncertain etiopathogenesis. A number of treatments have been used in application to BMS, though without clearly successful results. The present study compares the improvement in BMS obtained as a result of different treatment modalities in relation to the clinical characteristics of the patients. Study Design: A retrospective cohort study was made of 115 patients with BMS (109 females and 6 males) subjected to different treatments with a view to improving the symptoms. The clinical variables examined included the duration of the disorder, the location of the burning sensation, its daily variations and relationship with meals. The parameters were measured using a visual analog scale (VAS) applied at baseline and again after two weeks of treatment. Results: The mean patient age was 70±11.41 years, and the mean duration of the syndrome was 7.16±2.63 years. The tongue was the most frequently affected location. Anxiolytic treatment afforded the best results (p<0.001), and the patients with the shortest duration of disease showed the best improvement with treatment (p=0.005). Conclusion: The greatest treatment efficacy corresponded to anxiolytic drugs, and treatment was more effective when introduced early after the diagnosis of BMS.

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“…Studies support the use of tricyclic antidepressants (10-40 mg), including amitryptyline, desipramine, nortryptline, imipramine and clomipramine. The beneficial effects of tricyclic antidepressants in decreasing chronic pain indicate that in low doses these agents may act as analgesics 21 . Studies suggest the use of combination of medications in treatment of Burning mouth syndrome rather than higher doses of single medication, especially with regard to controlling adverse effects.…”

Section: Home Remedies For Burning Mouth Syndromementioning

confidence: 99%